Evidence map›Paper›PMID 28410554›Full record

ArticleNanoscale research letters2017

Yolk @ cage-Shell Hollow Mesoporous Monodispersion Nanospheres of Amorphous Calcium Phosphate for Drug Delivery with High Loading Capacity.

Suping Huang, Chunxia Li, Qi Xiao

Abstract read
In one paragraph

Article in Nanoscale research letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suping HuangState Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, Hunan, China. huangsp1@csu.edu.cn.
Chunxia LiState Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, Hunan, China.
Qi XiaoSchool of Resources Processing and Bioengineering, Central South University, Changsha, 410083, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, yolk-shell hollow nanospheres of amorphous calcium phosphate (ACP) are prepared, and its loading capacity is investigated by comparing with that of solid-shell hollow structure ACP and cage-shell hollow structure ACP. Results show that the products are yolk @ cage-shell of ACP with large shell's pores size (15-40 nm) and large cavity volume. Adsorption results show that the loading capacity of yolk @ cage-shell hollow spherical ACP is very high, which is more than twice that of hollow ACP and 1.5 times of cage-like ACP. The main reasons are that the big shell's pore size contributes the large molecular doxorubicin hydrochloride (DOX · HCl) to enter the inner of hollow spheres easier, and the yolk-shell structure provides larger interior space and more adsorption sites for loading drugs.

Indexed as

Amorphous calcium phosphateDOX · HClLoading capacityYolk @ cage-shell hollow nanospheres

Identifiers

PMID28410554
PMCPMC5391342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.