ArticleEnvironmental research2017
Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Association of arsenic exposure with PDGF-BB in vitro and in a South Texas population exposed through drinking water.Toxicology and applied pharmacology · 2025Article
- Association between history of miscarriage and autism spectrum disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Perinatal Metal and Metalloid Exposures and Offspring Cardiovascular Health Risk.Current environmental health reports · 2022Review
- Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Exposure to arsenolipids and inorganic arsenic from marine-sourced dietary supplements.Chemosphere · 2022Article
- Arsenic exposure from drinking water and endothelial dysfunction in Bangladeshi adolescents.Environmental research · 2022Article
- Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats.Frontiers in medicine · 2022Article
- Environmental Factors Involved in Maternal Morbidity and Mortality.Journal of women's health (2002) · 2021Article
- Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles.Journal of exposure science & environmental epidemiology · 2021Article
- Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.Environmental health : a global access science source · 2019Article
- Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.Environmental health : a global access science source · 2019Article
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
- Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study.Environmental health perspectives · 2017Article
- Dietary B Vitamin Intake Is Associated with Lower Urinary Monomethyl Arsenic and Oxidative Stress Marker 15-FThe Journal of nutrition · 2017Article
- Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAccumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking.
methodsWe examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1).
resultsCompared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2ng/ml (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3ng/ml (95% CI -56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8ng/ml (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFα in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (β
conclusionOur observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations.
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