Evidence map›Paper›PMID 28409845›Full record

Observational studyClinical cardiology2017

Procedural success and intra-hospital outcome related to left atrial appendage morphology in patients that receive an interventional left atrial appendage closure.

Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Ibrahim El-Battrawy, Uzair Ansari, Ishar-Singh Gill, Martin Borggrefe, Ibrahim Akin

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Risk factors, clinical implications, and management of peridevice leak following left atrial appendage closure: A systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  2. Meta-Analysis Comparing WatchmanFrontiers in cardiovascular medicine · 2020
    Pooled it
  3. Review
  4. Article
  5. Observational
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian FastnerFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Michael BehnesFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Benjamin SartoriusFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Annika WenkeFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Ibrahim El-BattrawyFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Uzair AnsariFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Ishar-Singh GillFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Martin BorggrefeFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Ibrahim AkinFirst Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interventional left atrial appendage (LAA) closure represents an emerging alternative to oral anticoagulation for stroke prevention in certain atrial fibrillation patients. Preliminary results have suggested high procedural success rates and fewer peri-interventional complications; however, there persists an insufficient understanding of the role of many underlying confounding variables (e.g., anatomical characteristics). HYPOTHESIS: It was investigated whether varying LAA morphologies influence procedural success as well as in-hospital outcome.

methodsSixty-seven patients ineligible for long-term oral anticoagulation were included in this single-center, prospective, observational registry spanning from the years 2014 to 2016. Interventions were performed with the Watchman occluder (Boston Scientific, Natick, MA) or the Amplatzer Amulet (St. Jude Medical, St. Paul, MN), at the operator's discretion. Results derived from the data describing procedural success, fluoroscopy, and peri-interventional safety events were classified according to the presenting LAA morphology (cauliflower, cactus, windsock, and chicken wing).

resultsRates of successful implantation were high across all groups (≥98%; P = 0.326). Surrogate parameters underlining procedural complexity like median total duration (P = 0.415), median fluoroscopy time (P = 0.459), median dose area product (P = 0.698), and the median amount of contrast agent (P = 0.076) demonstrated similar results across all groups. Likewise, the periprocedural complication rate was not significantly different and was mainly restricted to minor bleeding events.

conclusionsIrrespective of the varying morphological presentation of the LAA, the procedural success rates, interventional characteristics, and safety events did not significantly differ among patients receiving an interventional LAA closure.

Indexed as

Cardiac CatheterizationEchocardiography, TransesophagealRadiography, InterventionalAgedAged, 80 and overAtrial AppendageAtrial FibrillationElectrocardiographyFemaleFluoroscopyGermanyHumansMalePredictive Value of TestsProspective StudiesRegistriesAtrial FibrillationInterventional ComplicationsLeft Atrial AppendageLeft Atrial Appendage MorphologyProcedural Characteristics

Identifiers

PMID28409845
PMCPMC6490384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.