Evidence map›Paper›PMID 28409749›Full record

ArticleJournal of Parkinson's disease2017

The Role of Stress as a Risk Factor for Progressive Supranuclear Palsy.

Kristen D Kelley, Guerry Peavy, Steven Edland, Whitney Rogers, David E Riley, Yvette Bordelon, David Standaert, Stephen G Reich, Irene Litvan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristen D KelleyUC San Diego, School of Medicine, La Jolla, CA, USA.
Guerry PeavyDepartment of Neurosciences, UC San Diego, La Jolla, CA, USA.
Steven EdlandDepartment of Neurosciences, UC San Diego, La Jolla, CA, USA.
Whitney RogersDepartment of Neuroscience Training, University of Louisville, Louisville, KY, USA.
David E RileyDepartment of Neurology, Case Western Reserve University, Cleveland, OH, USA.
Yvette BordelonDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
David StandaertDepartment of Neurology, University of Alabama in Birmingham, Birmingham, AL, USA.
Stephen G ReichDepartment of Neurology, University of Maryland, Baltimore, MD, USA.
Irene LitvanDepartment of Neurosciences, UC San Diego, La Jolla, CA, USA.

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
Torsin Function in DrosiphilaP01NS037409 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI RAMESH, VIJAYA · 1999 to 2007
$8.5M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Mechanisms of LRRK2 Mediated NeurotoxicityR01NS064934 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEST, ANDREW B · 2010 to 2025
$6.3M
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
Genetic and Environmental Risk Factors for PSPR01AG024040 · NIA · UNIVERSITY OF LOUISVILLE · PI LITVAN, IRENE · 2006 to 2010
$2.7M
UAB Research Education Program for Residents and Fellows in NeuroscienceR25NS079188 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STANDAERT, DAVID G. · 2012 to 2022
$1.1M
The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD PatientsK23NS080912 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMARA, AMY WILLIS · 2012 to 2016
$934k
The Role of Astrocytes in Huntington's DiseaseK01NS069614 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRAY, MICHELLE · 2010 to 2014
$874k
San Diego Clinical and Translational Research InstituteTL1TR000098 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$860k
Validation of the JAK/STAT Signaling Pathway in PDP20NS092530 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STANDAERT, DAVID G. · 2015 to 2016
$642k
NCATS NIH HHS TL1 TR000098NCATS NIH HHS TL1 TR001443NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG024040NINDS NIH HHS F31 NS081963NINDS NIH HHS F31 NS084722NINDS NIH HHS K01 NS069614NINDS NIH HHS K23 NS080912NINDS NIH HHS P01 NS037409NINDS NIH HHS P20 NS092530NINDS NIH HHS R01 NS064934NINDS NIH HHS R25 NS079188NINDS NIH HHS U01 NS086659NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

backgroundPSP, like Alzheimer's disease (AD), is a tauopathy. The etiopathogenesis of PSP is not well known and the role of stress has not yet been examined. Recent studies have shown that stress increases the risk for developing AD. This study investigates the role of stress as a risk factor for PSP.

objectiveB To examine the association between the development of progressive supranuclear palsy (PSP) and self-reported life stressors.

methods76 patients diagnosed with PSP according to the NINDS-SPSP criteria and 68 age-matched unrelated controls were administered a life stressor questionnaire. Stress was quantified as total number of events, number of life changing events, and number of events characterized by self-rated severity. Conditional odds ratio (OR) was calculated for each measure, with participants in the highest quartile of each measure being defined as high-exposure in relation to all other participants.

resultsThere were no significant differences between the reported number of total events or life-changing events in cases and controls. However, we found 24.4% of cases (N = 11) and 9.1% of controls (N = 5) had a higher exposure to high severity events, yielding an OR of 3.2 (p = 0.04).

conclusionsWe found that cases have over a three times greater odds of high exposure to high-severity events than controls prior to the clinical development of PSP, while there were no differences in overall number of reported events. Our findings suggest that high exposure to highly stressful events may be associated with the development of PSP.

Indexed as

AgedCase-Control StudiesFemaleHumansMaleRisk FactorsSelf ReportStress, PsychologicalSupranuclear Palsy, Progressivecase-controlepidemiologyProgressive supranuclear palsy (PSP)stress

Identifiers

PMID28409749
PMCPMC5952610

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.