Evidence map›Paper›PMID 28409622›Full record

ArticleBiochemistry2017

The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP.

Zephan Melville, Erick O Hernández-Ochoa, Stephen J P Pratt, Yewei Liu, Adam D Pierce, Paul T Wilder, Kaylin A Adipietro, Daniel H Breysse, Kristen M Varney, Martin F Schneider and 1 more

Abstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. MMP1 and PRSS23 induce PARCommunications biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Structural insights into the regulation of RyR1 by S100A1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. Article
  10. Role of CaFrontiers in molecular neuroscience · 2022
    Review
  11. Article
  12. Cellular and molecular mechanisms of sarcopenia: the S100B perspective.Journal of cachexia, sarcopenia and muscle · 2018
    Review
  13. Loss of S100A1 expression leads to CaPhysiological reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zephan MelvilleDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.ORCID 0000-0001-8962-2612
Erick O Hernández-OchoaDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Stephen J P PrattDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Yewei LiuDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Adam D PierceDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Paul T WilderDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Kaylin A AdipietroDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Daniel H BreysseDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Kristen M VarneyDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
Martin F SchneiderDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
David J WeberDepartment of Biochemistry and Molecular Biology and ‡Center for Biomolecular Therapeutics, University of Maryland School of Medicine , 108 North Greene Street, Baltimore, Maryland 21201, United States.
University of Maryland, Baltimore · US

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Restoration of Tumor Suppression Activity in Malignant MelanomaR01CA107331 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 2006 to 2015
$5.4M
Roles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signalingR37AR055099 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHNEIDER, MARTIN F · 2012 to 2021
$3.5M
The Structure and Function of S100 ProteinsR01GM058888 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 1999 to 2010
$3.4M
Transmission Electron MicroscopeS10RR017741 · NCRR · UNIVERSITY OF MISSOURI-COLUMBIA · PI KATZ, MARTIN L · 2006 to 2006
$415k
NCI NIH HHS R01 CA107331NCRR NIH HHS S10 RR017741NIAMS NIH HHS R37 AR055099NIAMS NIH HHS T32 AR007592NIGMS NIH HHS R01 GM058888
6 · The paper itself

Abstract

Biochemical and structural studies demonstrate that S100A1 is involved in a Ca

Indexed as

Calcium SignalingActive Transport, Cell NucleusAnimalsCells, CulturedCyclic AMP-Dependent Protein Kinase RIIalpha SubunitCyclic AMP-Dependent Protein Kinase RIIbeta SubunitEnzyme ActivationGreen Fluorescent ProteinsHistone DeacetylasesHumansMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMuscle Fibers, SkeletalProtein SubunitsCyclic AMP-Dependent Protein Kinase RIIalpha SubunitCyclic AMP-Dependent Protein Kinase RIIbeta SubunitGreen Fluorescent ProteinsHdac5 protein, mouseHistone DeacetylasesPrkar2a protein, mousePrkar2b protein, mouseProtein SubunitsRecombinant Fusion ProteinsRecombinant ProteinsS100A1 proteinS100 Proteins

Identifiers

PMID28409622
PMCPMC5415871
OpenAlexW2606073259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.