Evidence map›Paper›PMID 28409534›Full record

ArticleBeneficial microbes2017

Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.

C A Danilo, E Constantopoulos, L A McKee, H Chen, J A Regan, Y Lipovka, S Lahtinen, L K Stenman, T-V V Nguyen, K P Doyle and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beneficial microbes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Cardioprotective Effect ofInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Probiotic Therapy withMicroorganisms · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. American journal of physiology. Heart and circulatory physiology · 2020
    Article
  17. Review
  18. Review
  19. Nutrients · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C A Danilo1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
E Constantopoulos1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
L A McKee1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
H Chen1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
J A Regan1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
Y Lipovka1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.
S Lahtinen2 DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, 02460 Kantvik, Finland.
L K Stenman2 DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, 02460 Kantvik, Finland.
T-V V Nguyen3 Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
K P Doyle3 Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
M J Slepian6 Department of Medicine, University of Arizona, Tucson, AZ 85721, USA.
Z I Khalpey7 Department Surgery, University of Arizona, Tucson, AZ 85721, USA.
J P Konhilas1 Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyR01HL098256 · NHLBI · UNIVERSITY OF ARIZONA · PI KONHILAS, JOHN P · 2010 to 2014
$1.9M
Metabolism, Skeletal Muscle, Cardiac Disease, ExerciseK01AR052840 · NIAMS · UNIVERSITY OF COLORADO · PI KONHILAS, JOHN P · 2006 to 2010
$600k
Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyK02HL105799 · NHLBI · UNIVERSITY OF ARIZONA · PI KONHILAS, JOHN P · 2011 to 2015
$516k
NHLBI NIH HHS K02 HL105799NHLBI NIH HHS R01 HL098256NHLBI NIH HHS T32 HL007249NIAMS NIH HHS K01 AR052840
6 · The paper itself

Abstract

There is a growing appreciation that our microbial environment in the gut plays a critical role in the maintenance of health and the pathogenesis of disease. Probiotic, beneficial gut microbes, administration can directly attenuate cardiac injury and post-myocardial infarction (MI) remodelling, yet the mechanisms of cardioprotection are unknown. We hypothesised that administration of Bifidobacterium animalis subsp. lactis 420 (B420), a probiotic with known anti-inflammatory properties, to mice will mitigate the pathological impact of MI, and that anti-inflammatory T regulatory (T

Indexed as

Bifidobacterium animalisLigilactobacillus salivariusAnimalsAnti-Inflammatory AgentsCardiotonic AgentsDietary SupplementsInflammationMaleMiceMice, Inbred C57BLMyocardial InfarctionProbioticsT-Lymphocytes, RegulatoryAnti-Inflammatory AgentsCardiotonic AgentsB. animalis ssp. lactiscardiovascular diseaseinflammationprobioticsregulatory T cells

Identifiers

PMID28409534
PMCPMC5815367

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.