ArticleIntensive care medicine experimental2017
The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances.
Article in Intensive care medicine experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Influence of oxygen enriched gases during decompression on bubble formation and endothelial function in self-contained underwater breathing apparatus diving: a randomized controlled study.Croatian medical journal · 2019Trial
- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury.Clinical and translational medicine · 2025Review
- Dynamic behavior and lineage plasticity of the pulmonary venous endothelium.Nature cardiovascular research · 2024Article
- Protective Effects of Beta-3 Adrenoceptor Agonism on Mucosal Integrity in Hyperoxia-Induced Ileal Alterations.Antioxidants (Basel, Switzerland) · 2024Article
- Effects of Oxygen Prebreathing on Bubble Formation, Flow-Mediated Dilatation, and Psychomotor Performance during Trimix Dives.Sports (Basel, Switzerland) · 2024Article
- Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries.Antioxidants (Basel, Switzerland) · 2023Review
- Cerebral Oxygen Delivery and Consumption in Brain-Injured Patients.Journal of personalized medicine · 2022Review
- Effects of Acute Hypobaric Hypoxia Exposure on Cardiovascular Function in Unacclimatized Healthy Subjects: A "Rapid Ascent" Hypobaric Chamber Study.International journal of environmental research and public health · 2022Article
- Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction.International journal of environmental research and public health · 2022Article
- Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.Frontiers in pharmacology · 2022Article
- NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species.Frontiers in pharmacology · 2022Article
- Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches.Redox biology · 2021Article
- miR-181c-5p mediates apoptosis of vascular endothelial cells induced by hyperoxemia via ceRNA crosstalk.Scientific reports · 2021Article
- Review of Design Considerations for Brain-on-a-Chip Models.Micromachines · 2021Review
- Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions.Physiological reports · 2021Article
- Revisited Hyperoxia Pathophysiology in the Perioperative Setting: A Narrative Review.Frontiers in medicine · 2021Review
- Biological effects of the oxygen molecule in critically ill patients.Journal of intensive care · 2020Review
- Hyperoxia in portal vein causes enhanced vasoconstriction in arterial vascular bed.Scientific reports · 2020Article
- Alda-1 attenuates hyperoxia-induced mitochondrial dysfunction in lung vascular endothelial cells.Aging · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperoxia, an arterial oxygen pressure of more than 100 mmHg or 13% O
methodshMVEC of the systemic circulation were exposed to graded oxygen fractions of 20, 30, 50, and 95% O
resultsExposing hMVEC to 50 and 95% O
conclusionsExposure of isolated human microvascular endothelial cells to marked hyperoxia for more than 24 h decreases cell viability and proliferation. Our results do not support a role of eNOS mRNA and protein or ET-1 mRNA in the potential vasoconstrictive effects of hyperoxia on isolated hMVEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.