Trial reportEuropean journal of applied physiology2017
The effect of high-intensity aerobic interval training on markers of systemic inflammation in sedentary populations.
Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 10 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Number of Sprint Repetitions in a Sprint Interval Training Session Does Not Moderate Improvements in V̇OScandinavian journal of medicine & science in sports · 2026Pooled it
- Acute and chronic effects of high-intensity interval training on selected exerkine secretion in health, disease, and aging: a systematic review.Frontiers in physiology · 2025Pooled it
- A meta-analysis of the effects of high-intensity interval training on circulatory system-related indicators in sedentary populations.Frontiers in physiology · 2025Pooled it
- Effect of HIIT on hemostasis and vascular stiffness: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2025Pooled it
- Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- High-Intensity Interval Training and Cardiometabolic Health in the General Population: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly.International journal of environmental research and public health · 2022Pooled it
- Systematic Review and Meta-Analysis on the Rehabilitation Effect of Different Intensity Exercise on the Patients with Cardiovascular Diseases.Computational and mathematical methods in medicine · 2022Pooled it
- The exercise-induced inflammatory response in inflammatory bowel disease: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Pooled it
- Physical Adaptations to High-Intensity Multimodal Training in Recreationally Active Adults: A Randomised Control Trial.European journal of sport science · 2026Trial
- Review
- The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cellsIn vitro models · 2023Article
- The effect of Tabata-style functional high-intensity interval training on cardiometabolic health and physical activity in female university students.Frontiers in physiology · 2023Article
- Beneficial Effects of Linseed Supplementation on Gut Mucosa-Associated Microbiota in a Physically Active Mouse Model of Crohn's Disease.International journal of molecular sciences · 2022Article
- Exercise training modulates adipokine dysregulations in metabolic syndrome.Sports medicine and health science · 2022Review
- Exercise Training Protocols to Improve Obesity, Glucose Homeostasis, and Subclinical Inflammation.Methods in molecular biology (Clifton, N.J.) · 2022Review
- The Impact of Acute and Chronic Exercise on Immunoglobulins and Cytokines in Elderly: Insights From a Critical Review of the Literature.Frontiers in immunology · 2021Review
- Effect of Exercise Training on Fat Loss-Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution.Frontiers in physiology · 2021Review
- Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study examined the effects of high-intensity interval training (HIIT; 30 s sprint, 4-5 min passive recovery) and prolonged intermittent sprint training (PIST; 10 s sprint, 2-3 min moderate exercise) on the systemic inflammatory markers C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α), aerobic capacity, and anthropometry in a middle-aged, sedentary population.
methodsFifty-five sedentary adults (age 49.2 ± 6.1 years) were randomised into HIIT (n = 20), PIST (n = 21), or a sedentary control group (CTRL n = 14). HIIT and PIST performed three training sessions per week for 9 weeks on a cycle ergometer, matched for total high-intensity time, while CTRL continued normal sedentary behaviours. Pre- and post-intervention testing involved measures of anthropometry, peak oxygen consumption (VO
resultsHIIT and PIST increased VO
conclusionsIn sedentary individuals, 9 weeks of HIIT or PIST were effective to improve aerobic capacity; however, only HIIT significantly reduced waist girth and WHR compared to CTRL. Markers of systemic inflammation remained unchanged across all groups. Accordingly, for inflammation and VO2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.