Evidence map›Paper›PMID 28409355›Full record

ArticleEuropean radiology2017

Percutaneous MR-guided focal cryoablation for recurrent prostate cancer following radiation therapy: retrospective analysis of iceball margins and outcomes.

Christiaan G Overduin, Sjoerd F M Jenniskens, J P Michiel Sedelaar, Joyce G R Bomers, Jurgen J Fütterer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  9. Image-Guided Prostate Cryoablation: State-of-the-Art.Medicina (Kaunas, Lithuania) · 2023
    Review
  10. Article
  11. Article
  12. Motorized template for MRI-guided focal cryoablation of prostate cancer.IEEE transactions on medical robotics and bionics · 2023
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christiaan G OverduinDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101 (767), 6500 HB, Nijmegen, The Netherlands. kristian.overduin@radboudumc.nl.
Sjoerd F M JenniskensDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101 (767), 6500 HB, Nijmegen, The Netherlands.
J P Michiel SedelaarDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Joyce G R BomersDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101 (767), 6500 HB, Nijmegen, The Netherlands.
Jurgen J FüttererDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, P.O. Box 9101 (767), 6500 HB, Nijmegen, The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate iceball margins after magnetic resonance (MR)-guided focal salvage prostate cryoablation and determine the correlation with local outcome.

methodsA retrospective review was performed on 47 patients that underwent percutaneous MR-guided focal cryoablation for biopsy-proven locally recurrent prostate cancer after primary radiotherapy. Preprocedural diagnostic and intraprocedural MR images were analysed to derive three-directional iceball margins. Local tumour progression after cryoablation was defined as evident tumour recurrence on follow-up MRI, positive MR-guided biopsy or biochemical failure without radiological evidence of metastatic disease.

resultsMean iceball margins were 8.9 mm (range -7.1 to 16.2), 10.1 mm (range 1.1-20.3) and 12.5 mm (range -1.5 to 22.2) in anteroposterior, left-right and craniocaudal direction respectively. Iceball margins were significantly smaller for tumours that were larger (P = .008) or located in the posterior gland (P = .047). Significantly improved local progression-free survival at 1 year post focal cryoablation was seen between patients with iceball margin >10 mm (100%), 5-10 mm (84%) and <5 mm (15%) (P < .001).

conclusionsIceball margins appear to correlate with local outcome following MR-guided focal salvage prostate cryoablation. Our initial data suggest that freezing should be applied at minimum 5 mm beyond the border of an MR-visible recurrent prostate tumour for successful ablation, with a wider margin appearing desirable. KEY POINTS: • Shortest iceball margin most often occurred in anteroposterior direction • Margins were smaller in tumours that were larger or posteriorly located • Minimum iceball margin was a predictor of early local tumour progression • A minimum 5-mm margin seems required for effective cryoablation of recurrent PCa.

Indexed as

Magnetic Resonance ImagingAgedBiopsyCryosurgeryDisease-Free SurvivalDisease ProgressionHumansMaleMiddle AgedNeoplasm Recurrence, LocalProstatic NeoplasmsRetrospective StudiesSalvage TherapyAblation marginCryoablationLocal recurrenceMRIProstate cancer

Identifiers

PMID28409355
PMCPMC5635095
OpenAlexW2606722857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.