ArticleActa neuropathologica2017
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
Open access · hybridAbstract read
In one paragraph
Article in Acta neuropathologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2022Pooled it
- Constitutive neuronal expression and disease-associated upregulation of chitinases in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2026Review
- miR-196a reduces mutant Huntingtin aggregates by Rad23b-mediated degradation in Huntington's disease.Journal of biomedical science · 2026Article
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Article
- First Glance at Myeloid Leukaemia Factor 2 in Cardiomyocytes.Journal of cardiovascular development and disease · 2025Article
- C9orf72 hexanucleotide repeat expansions impair microglial response in ALS.Nature neuroscience · 2025Article
- Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.Nature communications · 2025Article
- Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis.Acta neuropathologica communications · 2025Article
- Review
- Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats.Frontiers in pharmacology · 2025Article
- Enhancing Transcriptomic Insights into Neurological Disorders Through the Comparative Analysis of Shapley Values.Current issues in molecular biology · 2024Article
- Aberrant protein aggregation in amyotrophic lateral sclerosis.Journal of neurology · 2024Review
- Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.ACS pharmacology & translational science · 2024Article
- ALS' Perfect Storm:Cells · 2024Review
- Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression.Advances in neurobiology · 2024Review
- Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.Frontiers in molecular neuroscience · 2024Review
- Review
- Toxicity ofLife science alliance · 2023Article
- Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity.Acta neuropathologica communications · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 2 countries.
Martin H SchludiGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Lore BeckerGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Lillian GarrettGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Tania F GendronDepartment of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Qihui ZhouGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Franziska SchreiberGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Bastian PopperDepartment of Anatomy and Cell Biology, Biomedical Center, Ludwig-Maximilians-University Munich, Großhaderner Str. 9, 82152, Planegg-Martinsried, Germany.
Leda DimouPhysiological Genomics, Biomedical Center, Ludwig-Maximilians-University Munich, Großhaderner Str. 9, 82152, Planegg-Martinsried, Germany.
Tim M StromInstitut für Humangenetik, Helmholtz Zentrum München, 85764, Munich, Germany.
Juliane WinkelmannMunich Cluster for System Neurology (SyNergy), Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Anne von ThadenGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Kristin RentzschGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Stephanie MayGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Meike MichaelsenGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Benjamin M SchwenkGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Jing TanInstitut für Neurogenomik, Helmholtz Zentrum München, 85764, Munich, Germany.
Benedikt SchoserDepartment of Neurology, Friedrich-Baur-Institute, Klinikum der Ludwig-Maximilians-Universität München, Ziemssenstr. 1a, 80336, Munich, Germany.
Marianne DieterichGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Sabine M HölterGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Wolfgang WurstGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Helmut FuchsGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Valerie Gailus-DurnerGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Martin Hrabe de AngelisGerman Mouse Clinic, Institute of Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Thomas KlopstockGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Thomas ArzbergerGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany.
Dieter EdbauerGerman Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Straße 17, 81377, Munich, Germany. dieter.edbauer@dzne.de.ORCID 0000-0002-7186-4653
German Center for Neurodegenerative Diseases · DEHelmholtz Zentrum München · DELudwig-Maximilians-Universität München · DEMayo Clinic in Florida · USTUM Klinikum · DEUniversität Ulm · DE
Funding
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MDefining the mechanisms of dipeptide repeat protein toxicity in C9orf72 ALS/FTDR01NS093865 · NINDS · STANFORD UNIVERSITY · PI GITLER, AARON D., PETRUCELLI, LEONARD · 2015 to 2016
$583kNINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS093865
Abstract
Translation of the expanded (ggggcc)
Indexed as
AnimalsBrain StemC9orf72 ProteinCalcium-Binding ProteinsCentral Nervous System DiseasesCytokinesDNA Repeat ExpansionEmbryo, MammalianGene Expression RegulationHippocampusHumansInclusion BodiesInflammationMiceMice, Inbred C57BLMice, TransgenicC9orf72 ProteinCalcium-Binding ProteinsCytokinesNuclear ProteinsALSC9orf72FTDFTLDMNDMouse modelNeurodegenerationNeurological disorder
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.