ReviewF1000Research2017
When TADs go bad: chromatin structure and nuclear organisation in human disease.
Review in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- CTCF-anchored chromatin loop dynamics during human meiosis.BMC biology · 2025Article
- Long G4-rich enhancers target promoters via a G4 DNA-based mechanism.Nucleic acids research · 2025Article
- Active enhancers: recent research advances and insights into disease.Biology direct · 2024Review
- Integrative Identification by Hi-C Revealed Distinct Advanced Structural Variations in Lung Adenocarcinoma Tissue.Phenomics (Cham, Switzerland) · 2023Article
- Enhancer Function in the 3D Genome.Genes · 2023Review
- Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons.Genomics, proteomics & bioinformatics · 2023Article
- Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells.Skeletal muscle · 2022Article
- Article
- Chromatin Conformation in Development and Disease.Frontiers in cell and developmental biology · 2021Review
- Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers.Bioinformatics (Oxford, England) · 2020Article
- Article
- Mechanisms of tissue and cell-type specificity in heritable traits and diseases.Nature reviews. Genetics · 2020Review
- Pan-cancer analysis of somatic mutations and epigenetic alterations in insulated neighbourhood boundaries.PloS one · 2020Article
- Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome.Cancers · 2019Article
- The role of 3D genome organization in development and cell differentiation.Nature reviews. Molecular cell biology · 2019Review
- Understanding the 3D genome: Emerging impacts on human disease.Seminars in cell & developmental biology · 2019Review
- The three-dimensional organization of the genome in cellular senescence and age-associated diseases.Seminars in cell & developmental biology · 2019Review
- Modeling double strand break susceptibility to interrogate structural variation in cancer.Genome biology · 2019Article
- Systematics for types and effects of DNA variations.BMC genomics · 2018Review
- Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies.High-throughput · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, including self-interacting domains called topologically associating domains (TADs). This arrangement is thought to bring enhancers into closer physical proximity with their target genes, which often are located hundreds of kilobases away in linear genomic distance. TADs are demarcated by boundary regions bound by architectural proteins, such as CTCF and cohesin, although much remains to be discovered about the structure and function of these domains. Recent studies of TAD boundaries disrupted in engineered mouse models show that boundary mutations can recapitulate human developmental disorders as a result of aberrant promoter-enhancer interactions in the affected TADs. Similar boundary disruptions in certain cancers can result in oncogene overexpression, and CTCF binding sites at boundaries appear to be hyper-mutated across cancers. Further insights into chromatin organisation, in parallel with accumulating whole genome sequence data for disease cohorts, are likely to yield additional valuable insights into the roles of noncoding sequence variation in human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.