ArticleF1000Research2016
A multi-scale computational model of the effects of TMS on motor cortex.
Article in F1000Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.Experimental brain research · 2018Trial
- Precision in Delivery, Variability in Response: A Multiscale Mechanistic Framework for Neuronavigated Transcranial Magnetic Stimulation.Brain sciences · 2026Review
- Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation.bioRxiv : the preprint server for biology · 2026Article
- Histologically Informed Multiscale Modeling of the Neuronal Elements Activated by TMS.bioRxiv : the preprint server for biology · 2026Article
- Standardizing TMS Intensity Across Different Coils Using Individualized Electric Field Modeling.Human brain mapping · 2026Article
- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Circuits in the motor cortex explain oscillatory responses to transcranial magnetic stimulation.Network neuroscience (Cambridge, Mass.) · 2024Article
- Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Review
- The effect of alterations of schizophrenia-associated genes on gamma band oscillations.Schizophrenia (Heidelberg, Germany) · 2022Article
- Dosing Transcranial Magnetic Stimulation of the Primary Motor and Dorsolateral Prefrontal Cortices With Multi-Scale Modeling.Frontiers in neuroscience · 2022Article
- Mapping of multiple muscles with transcranial magnetic stimulation: absolute and relative test-retest reliability.Human brain mapping · 2021Article
- A Physical Perspective to the Inductive Function of Myelin-A Missing Piece of Neuroscience.Frontiers in neural circuits · 2020Review
- Direct Electrical Stimulation in Electrocorticographic Brain-Computer Interfaces: Enabling Technologies for Input to Cortex.Frontiers in neuroscience · 2019Review
- Biophysically realistic neuron models for simulation of cortical stimulation.Journal of neural engineering · 2018Article
- Coupling Magnetically Induced Electric Fields to Neurons: Longitudinal and Transverse Activation.Biophysical journal · 2018Article
- Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study.Scientific reports · 2017Article
- The Effect of a Transcranial Channel as a Skull/Brain Interface in High-Definition Transcranial Direct Current Stimulation-A Computational Study.Scientific reports · 2017Article
- Multi-Scale Computational Models for Electrical Brain Stimulation.Frontiers in human neuroscience · 2017Review
- A multi-scale computational model of the effects of TMS on motor cortex.F1000Research · 2016Article
- Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detailed biophysical mechanisms through which transcranial magnetic stimulation (TMS) activates cortical circuits are still not fully understood. Here we present a multi-scale computational model to describe and explain the activation of different pyramidal cell types in motor cortex due to TMS. Our model determines precise electric fields based on an individual head model derived from magnetic resonance imaging and calculates how these electric fields activate morphologically detailed models of different neuron types. We predict neural activation patterns for different coil orientations consistent with experimental findings. Beyond this, our model allows us to calculate activation thresholds for individual neurons and precise initiation sites of individual action potentials on the neurons' complex morphologies. Specifically, our model predicts that cortical layer 3 pyramidal neurons are generally easier to stimulate than layer 5 pyramidal neurons, thereby explaining the lower stimulation thresholds observed for I-waves compared to D-waves. It also shows differences in the regions of activated cortical layer 5 and layer 3 pyramidal cells depending on coil orientation. Finally, it predicts that under standard stimulation conditions, action potentials are mostly generated at the axon initial segment of cortical pyramidal cells, with a much less important activation site being the part of a layer 5 pyramidal cell axon where it crosses the boundary between grey matter and white matter. In conclusion, our computational model offers a detailed account of the mechanisms through which TMS activates different cortical pyramidal cell types, paving the way for more targeted application of TMS based on individual brain morphology in clinical and basic research settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.