ReviewThe Japanese dental science review2016
Production and physiological role of NO in the oral cavity.
Review in The Japanese dental science review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- CB2 Receptor Activation Attenuates IL-1β-Induced Inflammatory Transcriptomic Networks in Human Gingival Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2026Article
- High-Color-Temperature Lighting Is Associated With Activation of MAPK/ERK-nNOS Signaling and MMP-2-Related Pathways in Ocular Tissues.Investigative ophthalmology & visual science · 2026Article
- Evaluation of Salivary Nitric Oxide Levels in Odontogenic Lesions.International journal of clinical pediatric dentistry · 2026Article
- Neuronal nitric oxide synthase expression in secretory cells of the human parotid and submandibular salivary glands: evidence from light and electron microscopy.Cell and tissue research · 2026Article
- Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study.Journal of periodontology · 2026Observational
- Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in a Saudi Sub-Population.Journal of clinical medicine · 2024Article
- Article
- The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?Journal of clinical medicine · 2023Review
- Exploring the Mystery of the Tetrahydrobiopterin Synthetic Defect Lethal MutantInternational journal of molecular sciences · 2022Article
- Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products.Biomedicines · 2021Review
- Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review.Clinical oral investigations · 2020Review
- Innate Immunity and Biological Therapies for the Treatment of Sjögren's Syndrome.International journal of molecular sciences · 2020Review
- Dietary Nitrite Drives Disease Outcomes in Oral Polymicrobial Infections.Journal of dental research · 2019Article
- Assessment of dental caries and salivary nitric oxide levels in children with dyspepsia.BMC oral health · 2019Article
- The Photomodulation Activity of Metformin Against Oral Microbiome.Journal of lasers in medical sciences · 2019Review
- Possible role of nicotine and cotinine on nitroxidative stress and antioxidant content in saliva of smokeless tobacco consumers.Practical laboratory medicine · 2018Article
- Effects of coenzyme QJournal of dental sciences · 2018Article
- Immediate Effect of Modified Bhramari Pranayama on Salivary Nitric Oxide Level among Type 2 Diabetes Mellitus with Xerostomia: A Randomized Controlled Trial.International journal of yogaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synthase (NOS), which has three identified isoforms: neuronal type NOS (nNOS), endothelial type NOS (eNOS), and inducible type NOS (iNOS). Different isoforms are expressed depending on the organs, tissues, and cells, and investigation of the types and functions of enzymes expressed in various tissues is underway. The oral cavity is a space in which marked changes have been detected in NO levels, and each tissue is constantly influenced by NO. NO is a component of saliva and is produced by oral bacteria in the oral cavity and released by NOS expressed in oral mucosa. NOS isoforms expressed under normal conditions differ among the oral organs. In addition, the overexpression of NOS was involved in carcinogenesis and tumor growth progression. This review summarized the expression of NOS and functions of NO in oral cavity organs, and their roles in diseases and the influences of treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.