Evidence map›Paper›PMID 28408888›Full record

ArticleFrontiers in physiology2017

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol.

Meng-Han Liu, An-Hsuan Lin, Hsin-Kuo Ko, Diahn-Warng Perng, Tzong-Shyuan Lee, Yu Ru Kou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  3. Vistusertib improves pulmonary inflammation and fibrosis by modulating inflammatory/oxidative stress mediators via suppressing the mTOR signalling.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
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  16. Evidence-based complementary and alternative medicine : eCAM · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Meng-Han LiuDepartment of Physiology, School of Medicine, National Yang-Ming UniversityTaipei, Taiwan.
An-Hsuan LinDepartment of Physiology, School of Medicine, National Yang-Ming UniversityTaipei, Taiwan.
Hsin-Kuo KoDepartment of Chest Medicine, Taipei Veterans General HospitalTaipei, Taiwan.
Diahn-Warng PerngDepartment of Chest Medicine, Taipei Veterans General HospitalTaipei, Taiwan.
Tzong-Shyuan LeeDepartment of Physiology, School of Medicine, National Yang-Ming UniversityTaipei, Taiwan.
Yu Ru KouDepartment of Physiology, School of Medicine, National Yang-Ming UniversityTaipei, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWNational Taipei University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary fibrosis is a severe and progressive disease that is characterized by an abnormal deposition of extracellular matrix, such as collagens. The pathogenesis of this disease may be initiated by oxidative damage of lung epithelial cells by fibrogenic stimuli, leading to lung inflammation, which in turn promotes various lung fibrotic responses. The profibrogenic effect of transforming growth factor-β1 (TGF-β1) on lung fibroblasts is crucial for the pathogenesis of this disease. Paeonol, the main phenolic compound present in the Chinese herb

Indexed as

bleomycincollagenlung fibroblastsmicepaeonolpulmonary fibrosispulmonary inflammationα-smooth muscle actin

Identifiers

PMID28408888
PMCPMC5374202
OpenAlexW2598265559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.