ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2017
Detection of genome, antigen, and antibodies in oral fluids from pigs infected with foot-and-mouth disease virus.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Environmental Sampling Using Shoe Booties for the Detection of Foot and Mouth Disease Virus in Animal Pens.Viruses · 2026Article
- Animal Welfare-Friendly Noninvasive Oral Fluid in Swine Diagnostics: Current Applications in Disease Monitoring, Key Challenges and Future Directions.Veterinary medicine international · 2026Review
- Rotavirus-specific neutralization assay enables evaluation of mucosal immune responses.Frontiers in immunology · 2025Article
- Article
- Validation of a competitive enzyme-linked immunosorbent assay to improve the serological diagnosis of swine vesicular disease.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Micro and Nanoscale Technologies for Diagnosis of Viral Infections.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
- Update on shedding and transmission routes of porcine haemotrophic mycoplasmas in naturally and experimentally infected pigs.Porcine health management · 2021Article
- Molecular Characterization of Southern African Territories 2 (SAT2) Serotype of Foot-and-Mouth Disease Virus from Nigeria in 2017 to 2018.Microbiology resource announcements · 2021Article
- Foot and Mouth Disease Vaccine Development and Challenges in Inducing Long-Lasting Immunity: Trends and Current Perspectives.Veterinary medicine (Auckland, N.Z.) · 2021Review
- Advanced "lab-on-a-chip" to detect viruses - Current challenges and future perspectives.Biosensors & bioelectronics · 2020Review
- Advances in the Diagnosis of Foot-and-Mouth Disease.Frontiers in veterinary science · 2020Review
- Guidelines for oral fluid-based surveillance of viral pathogens in swine.Porcine health management · 2020Review
- Adenovirus-Vectored Capsid Proteins of the Serotype A Foot-and-Mouth Disease Virus Protect Guinea Pigs Against Challenge.Frontiers in microbiology · 2020Article
- Vesicular disease in pigs inoculated with a recent Canadian isolate of Senecavirus A.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Article
- Competitive Luminex immunoassays for detection of antibodies to foot-and-mouth disease and vesicular stomatitis viruses in multiple susceptible hosts.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus nucleic acids and antibody response to pathogens can be measured using swine oral fluids (OFs). Detection of foot-and-mouth disease virus (FMDV) genome in swine OFs has previously been demonstrated. Virus isolation and viral antigen detection are additional confirmatory assays for diagnosing FMDV, but these methods have not been evaluated using swine OF. The objectives of this study were to further validate the molecular detection of FMDV in oral fluids, evaluate antigen detection and FMDV isolation from swine OFs, and develop an assay for isotypic anti-FMDV antibody detection in OFs. Ribonucleic acid (RNA) from FMDV was detected in OFs from experimentally infected pigs by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) from 1 day post-infection (dpi) to 21 dpi. Foot-and-mouth disease virus (FMDV) was isolated from OFs at 1 to 5 dpi. Additionally, FMDV antigens were detected in OFs from 1 to 6 dpi using a lateral flow immunochromatographic strip test (LFIST), which is a rapid pen-side test, and from 2 to 3 dpi using a double-antibody sandwich enzyme-linked immunosorbent assay (DAS ELISA). Furthermore, FMDV-specific immunoglobulin A (IgA) was detected in OFs using an isotype-specific indirect ELISA starting at dpi 14. These results further demonstrated the potential use of oral fluids for detecting FMDV genome, live virus, and viral antigens, as well as for quantifying mucosal IgA antibody response.
Indexed as
Identifiers
28408775PMC5370543W2745338045What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.