ArticleScience (New York, N.Y.)2017
Decarboxylative borylation.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 374 citations in OpenAlex.
- Iron-Catalyzed Dealkenylative Borylation of Alkenes via Ozonolysis.Journal of the American Chemical Society · 2026Article
- Dual Photoredox/Cobalt Catalysis Enabled Regiospecific Markovnikov Hydroboration of Unactivated Mono-, Di-, and Trisubstituted Alkenes.Nature communications · 2026Article
- Metal-free deoxygenative borylation of pyrazinyl ethersChemical science · 2026Article
- Review
- Nickel-catalyzed radical relay enabled chemoselective fluoroalkyl-borylation of [1.1.1]propellane under kinetic control.Science advances · 2026Article
- Asymmetric synthesis of chiral boronic esters featuring nonadjacent axial and flexible, acyclic central chirality.Science advances · 2025Article
- Radical Borylation of Alkyl Bromides by Photoinduced Halogen-Atom Transfer.Angewandte Chemie (International ed. in English) · 2025Article
- Late-Stage Photoredox-Catalyzed Aryl C-H Bond Diazomethylation with Atomic Carbon Reagents.Journal of the American Chemical Society · 2025Article
- Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes.Nature communications · 2024Article
- Photoinduced Triphenylphosphine and Iodide Salt Promoted Reductive Decarboxylative Coupling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mechanisms for radical reactions initiating fromBeilstein journal of organic chemistry · 2024Article
- Ni-Catalyzed 1,1- and 1,3-Aminoboration of Unactivated Alkenes.Journal of the American Chemical Society · 2023Article
- Covalent-reversible peptide-based protease inhibitors. Design, synthesis, and clinical success stories.Amino acids · 2023Review
- Visible-light-mediated synthesis of oxime estersRSC advances · 2023Article
- Red-light-mediated Barton decarboxylation reaction and one-pot wavelength-selective transformations.Chemical science · 2023Article
- Desulfurative Borylation of Small Molecules, Peptides, and Proteins.Journal of the American Chemical Society · 2023Article
- Photoredox-Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts.Angewandte Chemie (International ed. in English) · 2023Article
- Article
- Carbon-Centered Radicals in Protein Manipulation.ACS central science · 2023Review
- Modular Synthesis of (Borylmethyl)silanes through Orthogonal Functionalization of a Carbon Atom.Organic letters · 2023Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The widespread use of alkyl boronic acids and esters is frequently hampered by the challenges associated with their preparation. We describe a simple and practical method to rapidly access densely functionalized alkyl boronate esters from abundant carboxylic substituents. This broad-scope nickel-catalyzed reaction uses the same activating principle as amide bond formation to replace a carboxylic acid moiety with a boronate ester. Application to peptides allowed expedient preparations of α-amino boronic acids, often with high stereoselectivity, thereby facilitating synthesis of the alkyl boronic acid drugs Velcade and Ninlaro as well as a boronic acid version of the iconic antibiotic vancomycin. The reaction also enabled the discovery and extensive biological characterization of potent human neutrophil elastase inhibitors, which offer reversible covalent binding properties.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.