ArticleArchives of virology1988
Transcription of proto-oncogenes in Rous sarcoma virus infected and transformed chicken embryo cells.
Article in Archives of virology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
To evaluate an effect of infection by RSV on the transcriptional activity of proto-oncogenes, we tested 19 cellular oncogenes and the beta-actin gene performing "nuclear run on transcription assays" using nuclei isolated from RSV infected or transformed chick embryo cells (CEC). A drastic increase in the transcriptional activity of the c-fgr proto-oncogene and a slight increase of c-fos and c-myc could be observed in uninfected compared to RSV infected CEC. To distinguish between infection- and transformation-dependent alterations we used the transformation-defective temperature-sensitive RSV mutant strain NY 68. Ts NY 68 infected CEC maintained at the permissive temperature of 36 degrees C and exhibiting a transformed phenotype, displayed no significant differences in the transcriptional activity of the 19 proto-oncogenes when compared to ts NY 68 infected CEC maintained at the nonpermissive temperature of 42 degrees C and exhibiting a normal phenotype. We conclude that the alterations observed were caused by the viral infection and are not due to the process of transformation. No significant changes in the transcription rate of the investigated genes could be observed after shifting ts NY 68 infected CEC from 42 degrees C to 36 degrees C. In contrast, a shift of ts NY 68 infected CEC from 36 degrees C to 42 degrees C results, after 2 hours, in a transient increase of the c-fos transcription.
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