Evidence map›Paper›PMID 28408652›Full record

ArticleCirculation. Arrhythmia and electrophysiology2017

Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping.

David Hamon, Pradeep S Rajendran, Ray W Chui, Olujimi A Ajijola, Tadanobu Irie, Ramin Talebi, Siamak Salavatian, Marmar Vaseghi, Jason S Bradfield, J Andrew Armour and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 56 citations in OpenAlex.

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  20. Arrhythmia-Induced Cardiomyopathy: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

David HamonFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Pradeep S RajendranFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Ray W ChuiFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Olujimi A AjijolaFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Tadanobu IrieFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Ramin TalebiFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Siamak SalavatianFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Marmar VaseghiFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Jason S BradfieldFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
J Andrew ArmourFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Jeffrey L ArdellFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
Kalyanam ShivkumarFrom the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles. kshivkumar@mednet.ucla.edu.
Anna Needs Neuroblastoma Answers · US

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
ELECTROPHYSIOLOGICAL EFFECTS OF NEURAL REMODELING OF THE VENTRICLESR01HL084261 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM · 2006 to 2016
$3.4M
Antiarrhythmic Mechanisms of Bilateral Cardiac Sympathetic DecentralizationK08HL125730 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2015 to 2019
$833k
Distributed electrode system for high-fidelity cardio-neural mappingU18EB021799 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2015 to 2017
$640k
Myocardial infarction alters information processing within the intrinsic cardiac nervous systemF31HL127974 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJENDRAN, PRADEEP SUNDARAM · 2015 to 2017
$72k
NHLBI NIH HHS F31 HL127974NHLBI NIH HHS K08 HL125730NHLBI NIH HHS R01 HL084261NIBIB NIH HHS U18 EB021799NIH HHS OT2 OD023848
6 · The paper itself

Abstract

backgroundVariability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. The objective was to determine the effect of PVCs and CI on intrinsic cardiac nervous system function in generating cardiac neuronal and electric instability using a novel cardioneural mapping approach. METHODS AND

resultsIn a porcine model (n=8), neuronal activity was recorded from a ventricular ganglion using a microelectrode array, and cardiac electrophysiological mapping was performed. Neurons were functionally classified based on their response to afferent and efferent cardiovascular stimuli, with neurons that responded to both defined as convergent (local reflex processors). Dynamic changes in neuronal activity were then evaluated in response to right ventricular outflow tract PVCs with fixed short, fixed long, and variable CI. PVC delivery elicited a greater neuronal response than all other stimuli (

conclusionsVariable CI PVCs affect critical populations of intrinsic cardiac nervous system neurons and alter cardiac repolarization. These changes may be critical for arrhythmogenesis and remodeling, leading to cardiomyopathy.

Indexed as

Heart RateMyocardial ContractionVentricular FunctionAction PotentialsAnimalsAutonomic Nervous SystemCardiac Pacing, ArtificialCardiomyopathiesDisease Models, AnimalElectrophysiologic Techniques, CardiacFemaleHeartMaleSus scrofaTime FactorsVentricular Premature Complexesautonomic nervous systemcouplingintrinsic cardiac ganglianeurocardiologypremature ventricular beatsPVC-induced cardiomyopathy

Identifiers

PMID28408652
PMCPMC5407491
OpenAlexW2607169654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.