Evidence map›Paper›PMID 28408644›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT

Yogesh Bhattarai, Bradley A Schmidt, David R Linden, Eric D Larson, Madhusudan Grover, Arthur Beyder, Gianrico Farrugia, Purna C Kashyap

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026
    Review
  7. Article
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  9. Article
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  11. Article
  12. Article
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  17. Article
  18. Article
  19. Postoperative delayed gastric emptying: may gut microbiota play a role?Frontiers in cellular and infection microbiology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yogesh BhattaraiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Bradley A SchmidtDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
David R LindenDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Eric D LarsonDepartment of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado; and.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Arthur BeyderDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Purna C KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; kashyap.purna@mayo.edu.
Mayo Clinic · USWinnMed · USUniversity of Colorado Denver · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Tamas Ordog · 2009 to 2026
$22.2M
Mechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M
Mechanisms of mechanotransduction in the enterochromaffin cellsK08DK106456 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2015 to 2019
$813k
"Barrier function alterations in post-infectious irritable bowel syndrome"K23DK103911 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2015 to 2019
$804k
MECHANISMS OF ALTERATION OF GASTROINTESTINAL MOTILITY BY GUT MICROBIOTAK08DK100638 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2014 to 2017
$610k
Mechanisms of alteration of gastrointestinal physiology by gut microbesR03DK111850 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2017 to 2018
$159k
NIDDK NIH HHS K08 DK100638NIDDK NIH HHS K08 DK106456NIDDK NIH HHS K23 DK103911NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK114007NIDDK NIH HHS R03 DK111850
6 · The paper itself

Abstract

Serotonin [5-hydroxytryptamine (5-HT)], an important neurotransmitter and a paracrine messenger in the gastrointestinal tract, regulates intestinal secretion by its action primarily on 5-HT

Indexed as

AcetatesAnimalsColonGene Expression RegulationGerm-Free LifeHumansMiceMicrobiotaReceptors, Serotonin, 5-HT3Receptors, Serotonin, 5-HT4SerotoninAcetatesReceptors, Serotonin, 5-HT3Receptors, Serotonin, 5-HT4Serotonin5-hydroxytryptamine type 3irritable bowel syndromemicrobiomemotilityphysiologysecretion

Identifiers

PMID28408644
PMCPMC5538830
OpenAlexW2607428872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.