ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017
Gastroparesis and lipid metabolism-associated dysbiosis in Wistar-Kyoto rats.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Social Isolation Induces Sex-Specific Differences in Behavior and Gut Microbiota Composition in Stress-Sensitive Rats.Brain and behavior · 2025Article
- Application of lipidomics in the study of traditional Chinese medicine.Journal of pharmaceutical analysis · 2025Review
- Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study.Scientific reports · 2024Article
- Postoperative delayed gastric emptying: may gut microbiota play a role?Frontiers in cellular and infection microbiology · 2024Review
- Supplementation withFrontiers in immunology · 2024Article
- A Diet Enriched withInternational journal of molecular sciences · 2023Article
- Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study.Journal of translational medicine · 2022Article
- A Review on Drug Induced Obesity and Rodent Experimental Models of Obesity in Animals.Maedica · 2022Article
- Crosstalk BetweenFrontiers in pharmacology · 2021Article
- Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study.Nutrition & metabolism · 2020Article
- Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin bEuropean journal of drug metabolism and pharmacokinetics · 2019Article
- Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction.Scientific reports · 2019Article
- Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats.The Journal of veterinary medical science · 2019Article
- Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.Gut and liver · 2019Article
- Gastric Emptying and Gastrointestinal Transit Compared among Native and Hydrolyzed Whey and Casein Milk Proteins in an Aged Rat Model.Nutrients · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered gastric accommodation and intestinal morphology suggest impaired gastrointestinal (GI) transit may occur in the Wistar-Kyoto (WKY) rat strain, as common in stress-associated functional GI disorders. Because changes in GI transit can alter microbiota composition, we investigated whether these are altered in WKY rats compared with the resilient Sprague-Dawley (SD) rats under basal conditions and characterized plasma lipid and metabolite differences. Bead transit was tracked by X-ray imaging to monitor gastric emptying (4 h), small intestine (SI) transit (9 h), and large intestine transit (12 h). Plasma extracts were analyzed by lipid and hydrophilic interaction liquid chromatography (HILIC) and liquid chromatography-mass spectrometry (LC-MS). Cecal microbial composition was determined by Illumina MiSeq 16S rRNA amplicon sequencing and analysis using the QIIME pipeline. Stomach retention of beads was 77% for WKY compared with 35% for SD rats. GI transit was decreased by 34% (9 h) and 21% (12 h) in WKY compared with SD rats. Excluding stomach retention, transiting beads moved 29% further along the SI over 4-9 h for WKY compared with SD rats. Cecal
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