Evidence map›Paper›PMID 28408623›Full record

ArticleThe Journal of biological chemistry2017

Protein kinase D1 (PKD1) phosphorylation on Ser

Jen-Kuan Chang, Yang Ni, Liang Han, James Sinnett-Smith, Rodrigo Jacamo, Osvaldo Rey, Steven H Young, Enrique Rozengurt

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine.Journal of the American Chemical Society · 2025
    Article
  3. Article
  4. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jen-Kuan ChangFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine.
Yang NiFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine.
Liang HanFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine.
James Sinnett-SmithFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine.
Rodrigo Jacamothe Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4017, and.
Osvaldo Reythe Institute of Immunology, Genetics, and Metabolism, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos Aires, Buenos Aires C1120AAR, Argentina.
Steven H YoungFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine.
Enrique RozengurtFrom the Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, erozengurt@mednet.ucla.edu.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARThe University of Texas MD Anderson Cancer Center · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell RegulationR01DK100405 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 2014 to 2017
$1.3M
Calcium-sensing receptor signaling in the regulation of colonic epithelial cellsI01BX001473 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI ROZENGURT, JUAN ENRIQUE · 2012 to 2015
–
BLRD VA I01 BX001473NCI NIH HHS P01 CA163200NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK100405
6 · The paper itself

Abstract

Although PKC-mediated phosphorylation of protein kinase D1 (PKD1) has been extensively characterized, little is known about PKD1 regulation by other upstream kinases. Here we report that stimulation of epithelial or fibroblastic cells with G protein-coupled receptor agonists, including angiotensin II or bombesin, induced rapid and persistent PKD1 phosphorylation at Ser

Indexed as

Active Transport, Cell NucleusAnimalsCell LineCell MembraneCell NucleusMicep21-Activated KinasesPhosphorylationProtein Kinase CProtein Kinase InhibitorsRatsp21-Activated KinasesProtein Kinase Cprotein kinase DProtein Kinase Inhibitorsangiotensin IIG protein-coupled receptor (GPCR)protein kinase C (PKC)protein kinase D (PKD)serine/threonine-protein kinase PAK 1 (PAK1)

Identifiers

PMID28408623
PMCPMC5465480
OpenAlexW2605671583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.