Evidence map›Paper›PMID 28408461›Full record

ArticleBlood2017

Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations.

Shaoyan Hu, Maoxiang Qian, Hui Zhang, Yu Guo, Jin Yang, Xujie Zhao, Hailong He, Jun Lu, Jian Pan, Meimei Chang and 12 more

Registry-linked trialAbstract readLetter
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00137111 phase3completednot on this map

Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

TypeinterventionalSponsorSt. Jude Children's Research HospitalRan2000 to 2014Enrolled501ConditionsLymphoblastic Leukemia, AcuteArmsPrednisone, Dexamethasone, Vincristine, Daunorubicin, Doxorubicin, L-asparaginase, PEG-L-asparaginase, Erwinia asparaginase, Methotrexate, Cyclophosphamide, Cytarabine, Etoposide, Mercaptopurine, Imatinib, chemotherapy, intrathecal chemotherapy
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. Review
  3. Oncogenic Enhancers in Leukemia.Blood cancer discovery · 2024
    Review
  4. Acute lymphoblastic leukaemia.Nature reviews. Disease primers · 2024
    Review
  5. Article
  6. Review
  7. HemaSphere · 2024
    Article
  8. The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  9. Article
  10. Cell genomics · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Genomic and Clinical Analysis of Children with Acute Lymphoblastic Leukemia.Computational and mathematical methods in medicine · 2022
    Article
  16. Review
  17. Non-coding driver mutations in human cancer.Nature reviews. Cancer · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Shaoyan HuChildren's Hospital of Soochow University, Suzhou, Jiangsu, China.
Maoxiang QianDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Hui ZhangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Yu GuoGenome Institute of Singapore, Singapore.
Jin YangChildren's Hospital of Soochow University, Suzhou, Jiangsu, China.
Xujie ZhaoDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Hailong HeChildren's Hospital of Soochow University, Suzhou, Jiangsu, China.
Jun LuChildren's Hospital of Soochow University, Suzhou, Jiangsu, China.
Jian PanChildren's Hospital of Soochow University, Suzhou, Jiangsu, China.
Meimei ChangGenome Institute of Singapore, Singapore.
Guoqing DuDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Ting-Nien LinDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Shirley Kow-Yin KhamKhoo Teck Puat-National University Children's Medical Institute and.
Thuan Chong QuahKhoo Teck Puat-National University Children's Medical Institute and.
Hany AriffinPaediatric Haematology-Oncology Unit, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Ah-Moy TanKKH-CCF Children's Cancer Centre, Paediatric Haematology & Oncology, KK Women's and Children's Hospital, Singapore; and.
Yong ChengDepartment of Hematology.
Chunliang LiDepartment of Tumor Cell Biology.
Allen Eng-Juh YeohKhoo Teck Puat-National University Children's Medical Institute and.
Ching-Hon PuiDepartment of Oncology, and.
Anders Jacobsen SkanderupGenome Institute of Singapore, Singapore.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Enhancer Elements, GeneticGenetic LociGenome-Wide Association StudyMutationFemaleHumansMalePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

Identifiers

PMID28408461
PMCPMC5472902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.