ArticleThe Journal of experimental medicine2017
Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior.
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
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- The role of lymphocytic CD5 in the effects of ethanol on mesolimbic circuitry and ethanol consumption behavior.Brain, behavior, and immunity · 2026Article
- Allele-Specific Regulation of PAXIP1-AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Learning induces persistent chromatin loops underlying robust gene expression during memory recall.bioRxiv : the preprint server for biology · 2025Article
- Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum.Epigenetics & chromatin · 2025Article
- Sex-specific modulation of anxiety-like behavior by forebrain neuronal SMC3 in mice.Translational psychiatry · 2025Article
- Cohesin in 3D: development, differentiation, and disease.Genes & development · 2025Review
- Article
- Identification of a novel, pathogenicFrontiers in genetics · 2025Article
- Brain-Resident Immune Cells in Neurodevelopmental Disorders.Advances in experimental medicine and biology · 2025Review
- Three-dimensional chromatin mapping of sensory neurons reveals that promoter-enhancer looping is required for axonal regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration.bioRxiv : the preprint server for biology · 2024Article
- Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.International journal of molecular sciences · 2024Article
- Deciphering the Role of Rapidly Evolving Conserved Elements in Primate Brain Development and Exploring Their Potential Involvement in Alzheimer's Disease.Molecular biology and evolution · 2024Article
- Debiased personalized gene coexpression networks for population-scale scRNA-seq data.Genome research · 2023Article
- Dozer: Debiased personalized gene co-expression networks for population-scale scRNA-seq data.bioRxiv : the preprint server for biology · 2023Article
- Phenotypes and Genotypes in Patients withGenes · 2023Article
- Unique aspects of IFN-γ/STAT1 signaling in neurons.Immunological reviews · 2022Review
- 3D spatial genome organization in the nervous system: From development and plasticity to disease.Neuron · 2022Review
- Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal epigenetic regulation can cause the nervous system to develop abnormally. Here, we sought to understand the mechanism by which this occurs by investigating the protein complex cohesin, which is considered to regulate gene expression and, when defective, is associated with higher-level brain dysfunction and the developmental disorder Cornelia de Lange syndrome (CdLS). We generated conditional
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.