ArticleBehavioural brain research2017
Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response.Biology of sex differences · 2026Article
- Effects of the estrous cycle and sex on stress responses in guinea pigs.Scientific reports · 2025Article
- Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.Frontiers in behavioral neuroscience · 2024Article
- Gender Differences in Cortisol and Cortisol Receptors in Depression: A Narrative Review.International journal of molecular sciences · 2023Review
- The Track-by-Day Method for Monitoring the Rodent Estrous Cycle.Current protocols · 2023Article
- Article
- Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.Behavioural brain research · 2023Article
- RETRACTED: Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat.Biology · 2022Article
- Article
- Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals.Neuroscience and behavioral physiology · 2022Article
- Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse.Developmental psychobiology · 2021Article
- Age-Related Individual Behavioural Characteristics of Adult Wistar Rats.Animals : an open access journal from MDPI · 2021Article
- Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy.The Journal of pharmacology and experimental therapeutics · 2020Review
- Stress as a potential moderator of ovarian hormone influences on binge eating in women.F1000Research · 2019Review
- d-Serine administration affects nitric oxide synthase 1 adaptor protein and DISC1 expression in sex-specific manner.Molecular and cellular neurosciences · 2018Article
- Maternal Deprivation Increases Anxiety- and Depressive-Like Behaviors in an Age-Dependent Fashion and Reduces Neuropeptide Y Expression in the Amygdala and Hippocampus of Male and Female Young Adult Rats.Frontiers in behavioral neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic social isolation could lead to a disruption in the Hypothalamic-Pituitary-Adrenal (HPA) axis, resulting in anxiety and depressive-like behaviors but cycling estrogens could modify these behaviors. The aim of this study was to determine if changes in ovarian hormones during the normal cycle could interact with social isolation to alter anxiety and depressive-like behaviors. In parallel, we examined the expression of glucocorticoid receptor (GR) and synaptic vesicle protein synaptophysin in the hippocampus and hypothalamus of Sprague Dawley normal cycling female rats. We assigned rats to either isolated or paired housing for 8 weeks. To assess anxiety and depressive-like behaviors, we used the open field test and forced swim test, respectively. Female rats were tested at either diestrus, estrus, or proestrus stage of the estrous cycle. After behaviors, rats were perfused and brains collected. Brain sections containing hippocampus and hypothalamus were analyzed using immunohistochemistry for synaptophysin and glucocorticoid receptor (GR) levels. We found an increase in depressive-like behaviors for isolated animals compared to paired housed rats, regardless of the estrous cycle stage. Interestingly, we found a decrease in anxiety behaviors in females in the estrus stage accompanied by a decrease in GR expression in hippocampal DG and CA3. However, no changes in synaptophysin were observed in any of the areas of studied. Our results support the beneficial effects of circulating ovarian hormones in anxiety, possibly by decreasing GR expression.
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Registered trials
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