Evidence map›Paper›PMID 28408205›Full record

ArticleDevelopmental biology2017

Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development.

Mehari Endale, Shawn Ahlfeld, Erik Bao, Xiaoting Chen, Jenna Green, Zach Bess, Matthew T Weirauch, Yan Xu, Anne Karina Perl

Open access · hybridAbstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.Journal of the American Heart Association · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. PdgfrαGenes & diseases · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. LungMAP Portal Ecosystem: Systems-level Exploration of the Lung.American journal of respiratory cell and molecular biology · 2024
    Article
  14. Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRAAmerican journal of respiratory cell and molecular biology · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. The lung mesenchyme in development, regeneration, and fibrosis.The Journal of clinical investigation · 2023
    Review
  19. Hedgehog and Platelet-derived Growth Factor Signaling Intersect during Postnatal Lung Development.American journal of respiratory cell and molecular biology · 2023
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mehari EndalePerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Shawn AhlfeldPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Erik BaoPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Xiaoting ChenCenter of Autoimmune Genomics and Ethology, USA.
Jenna GreenPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Zach BessPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Matthew T WeirauchCenter of Autoimmune Genomics and Ethology, USA; Divisions of Biomedical Informatics and Developmental Biology, USA.
Yan XuPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Anne Karina PerlPerinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. Electronic address: Anne.Perl@cchmc.org.
Cincinnati Children's Hospital Medical Center · USAutoimmune Technologies (United States) · US

Funding

"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Interstitial resident fibroblasts direct alveolar epithelial differentiationR01HL131661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2017 to 2020
$1.9M
FGF and PDGF regulate myofibroblast differentiation in alveolar regenerationR01HL104003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2010 to 2013
$1.5M
Effect of disease-associated genetic variants on viral protein DNA bindingR21HG008186 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2015 to 2017
$464k
Matrix fibroblasts are required for alveolar homeostasis and regrowthR56HL123969 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2015 to 2015
$390k
NHGRI NIH HHS R21 HG008186NHLBI NIH HHS R01 HL104003NHLBI NIH HHS R01 HL131661NHLBI NIH HHS R56 HL123969NHLBI NIH HHS U01 HL122642
6 · The paper itself

Abstract

Many studies have investigated the source and role of epithelial progenitors during lung development; such information is limited for fibroblast populations and their complex role in the developing lung. In this study, we characterized the spatial location, mRNA expression and Immunophenotyping of PDGFRα

Indexed as

AnimalsAntigens, CDBronchiCell DifferentiationEmbryo, MammalianEpitheliumFibroblastsGene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsImmunophenotypingLungMice, TransgenicMyocytes, Smooth MuscleMyofibroblastsPhenotypeAntigens, CDGreen Fluorescent ProteinsReceptor, Platelet-Derived Growth Factor alphaTranscription FactorsiReFLipofibroblastLungMAPMatrixfibroblastMyofibroblast

Identifiers

PMID28408205
PMCPMC5492510
OpenAlexW2606582949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.