ReviewDeutsches Arzteblatt international2017
Cardiovascular Comorbidity in Inflammatory Rheumatological Conditions.
Review in Deutsches Arzteblatt international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04197050 (Effect of Sacubitril/Valsartan on Right Ventricular Dysfunctioning Patients With Connective Tissue Disease), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sacubitril/Valsartan on Right Ventricular Dysfunctioning Patients With Connective Tissue Disease
Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Is there a link between non-steroidal anti-inflammatory drugs and cardiovascular risk in patients with inflammatory arthritis?Atherosclerosis plus · 2026Review
- Early detection of cardiac impairment and prediction of right ventricular hypertrophy in patients with connective tissue disease.Biomedical reports · 2025Article
- Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2025Article
- [Immune-mediated inflammatory diseases in Germany : A cross-sectional analysis of comorbidities and pharmacotherapy].Zeitschrift fur Rheumatologie · 2024Article
- Effects of ankylosing spondylitis on cardiovascular disease: aMendelian randomization study.Frontiers in genetics · 2024Article
- Disproportional signal of pericarditis with biological diseasemodifying antirheumatic drugs (bDMARDs) in patients with ankylosing spondylitis: a disproportionality analysis in the FAERS database.Frontiers in pharmacology · 2024Article
- Age-related etiologies of aortic regurgitation with moderate or greater severity and coronary cusp bending: evaluation using transesophageal echocardiography.Journal of medical ultrasonics (2001) · 2022Article
- Myeloperoxidase as an important predictor of cardiovascular risk in individuals with rheumatoid arthritis.Inflammopharmacology · 2021Article
- [Pericarditis is inflammation of the pericardium, which rheumatologists should know].Zeitschrift fur Rheumatologie · 2021Review
- Heart Involvement in a Moroccan Population with Spondyloarthritis: A Cross-sectional Study.Journal of the Saudi Heart Association · 2021Article
- Outcomes of Total Hip Arthroplasty in Patients With Acetabular Protrusio.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020Article
- [Rheumatological care in the Rheumazentrum Ruhrgebiet Rheumatism Center-a model for conurbations].Zeitschrift fur Rheumatologie · 2019Review
- [Complex treatments in rheumatology and geriatrics - Challenges - Differences - Chances].Zeitschrift fur Rheumatologie · 2018Review
- [Characteristics of pharmacotherapy in older patients with rheumatism].Zeitschrift fur Rheumatologie · 2018Review
- [Prevalence, comorbidity and interdisciplinary treatment of rheumatoid arthritis - Insurance data on outpatient and inpatient care in Baden-Württemberg].Zeitschrift fur Rheumatologie · 2018Article
- An unfavorable body composition is common in early arthritis patients: A case control study.PloS one · 2018Article
- Cardiac disease in familial Mediterranean fever.Rheumatology international · 2018Review
- Rheumatic Heart Disease Still Relevant.Deutsches Arzteblatt international · 2017Article
- Cardiovascular Comorbidities.Deutsches Arzteblatt international · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 1.5 million adults in Germany suffer from an inflammatory rheumatological condition. The most common among these are rheumatoid arthritis and spondyloarthritis-above all axial spondyloarthritis, including ankylosing spondylitis (Bekhterev's disease) and psoriatic arthritis. These systemic inflammatory diseases often affect the heart as well.
methodsThis review is based on pertinent articles retrieved by a selective literature search, on current European guidelines, and on the authors' clinical experience.
resultsRheumatic inflammation of cardiac structures can manifest itself as pericarditis, myocarditis, or endocarditis. The heart valves and the intracardiac conduction system can be affected as well, leading to AV block. Functional sequelae, e.g., congestive heart failure, can arise as a consequence of any inflammatory rheumatic disease. The long-term mortality of rheumatic diseases is elevated predominantly because of the increased risk for cardiovascular comorbidities. The cardiovascular risk profile should therefore be re-evaluated regularly (e.g., at 5-year intervals) in cooperation with the patient's primary care physician. The cardiovascular manifestations of rheumatic disease, such as pericarditis, myocarditis, and vasculitis, are treated initially with high-dose glucocorticoids and then over the long term with maintenance drugs such as methotrexate and azathioprine. Biological agents are sometimes used as well.
conclusionIn patients with inflammatory rheumatic diseases, the elevated cardiovascular risk should be kept in mind and preventive measures should be initiated early. This subject should be further studied in controlled trials so that the treatment options for patients with cardiac involvement can be evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.