Evidence map›Paper›PMID 28407741›Full record

ArticleJournal of neuroinflammation2017

The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis.

Sujata Prasad, Shuxian Hu, Wen S Sheng, Priyanka Chauhan, Amar Singh, James R Lokensgard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  6. AblatingFrontiers in immunology · 2026
    Article
  7. Alarm Functions of PD-1+ Brain-Resident Memory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sujata PrasadDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA.
Shuxian HuDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA.
Wen S ShengDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA.
Priyanka ChauhanDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA.
Amar SinghDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA.
James R LokensgardDepartment of Medicine, Neurovirology Laboratory, University of Minnesota, 3-107 Microbiology Research Facility, 689 23rd Avenue S.E., Minneapolis, MN, 55455, USA. loken006@umn.edu.
University of Minnesota · US

Funding

Role of B-cells and CNS antibodies in modulating chronic microglial activationR01NS038836 · NINDS · UNIVERSITY OF MINNESOTA · PI LOKENSGARD, JAMES R · 2000 to 2022
$7.3M
T lymphocyte-induced glial activation during CNS immune reconstitution diseaseR01MH066703 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOKENSGARD, JAMES R · 2003 to 2023
$6.9M
NIMH NIH HHS R01 MH066703NINDS NIH HHS R01 NS038836
6 · The paper itself

Abstract

backgroundPrevious work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting the deleterious consequences of unrestrained neuroinflammation. Here, we evaluated the PD-1: PD-L1 pathway in development of brain-resident memory T cells (bT

methodsFlow cytometric analysis of immune cells was performed at 7, 14, and 30 days post-infection (dpi) to assess the shift of brain-infiltrating CD8

resultsIn wild-type (WT) animals, we observed a switch in the phenotype of brain-infiltrating CD8

conclusionsTaken together, our results indicate that bT

Indexed as

AnimalsB7-H1 AntigenBrainCD8-Positive T-LymphocytesEncephalitis, ViralFemaleMiceMice, Inbred BALB CMice, KnockoutNIH 3T3 CellsProgrammed Cell Death 1 ReceptorSignal TransductionB7-H1 AntigenCd274 protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID28407741
PMCPMC5390367
OpenAlexW2605592326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.