Evidence map›Paper›PMID 28407726›Full record

Trial reportThe American journal of psychiatry2017

Complementary Features of Attention Bias Modification Therapy and Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders.

Lauren K White, Stefanie Sequeira, Jennifer C Britton, Melissa A Brotman, Andrea L Gold, Erin Berman, Kenneth Towbin, Rany Abend, Nathan A Fox, Yair Bar-Haim and 2 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03283930 (A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03283930 nacompletednot on this map

A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2016 to 2023Enrolled121ConditionsAnxiety DisordersArmsActive Attention Bias Modification Training, Placebo Attention Bias Modification Training
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  11. Gaze-Contingent Music Reward Therapy for Clinically Anxious 7- to 10-Year-Olds: An Open Multiple Baseline Feasibility Study.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial
  12. Article
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  16. Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025
    Review
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  19. Novel mechanism-based treatments for pediatric anxiety and depressive disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lauren K WhiteFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Stefanie SequeiraFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Jennifer C BrittonFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Melissa A BrotmanFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Andrea L GoldFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Erin BermanFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Kenneth TowbinFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Rany AbendFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Nathan A FoxFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Yair Bar-HaimFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Ellen LeibenluftFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Daniel S PineFrom NIMH, Bethesda, Md.; Children's Hospital of Philadelphia, Philadelphia; the Department of Psychology, University of Miami, Coral Gables, Fla.; the Child Development Laboratory, University of Maryland, College Park; and the Department of Psychology, Tel Aviv University, Tel Aviv.
Children's Hospital of Philadelphia · US

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Intramural NIH HHS Z99 MH999999
6 · The paper itself

Abstract

objectiveIn the treatment of anxiety disorders, attention bias modification therapy (ABMT) and cognitive-behavioral therapy (CBT) may have complementary effects by targeting different aspects of perturbed threat responses and behaviors. ABMT may target rapid, implicit threat reactions, whereas CBT may target slowly deployed threat responses. The authors used amygdala-based connectivity during a threat-attention task and a randomized controlled trial design to evaluate potential complementary features of these treatments in pediatric anxiety disorders.

methodPrior to treatment, youths (8-17 years old) with anxiety disorders (N=54), as well as healthy comparison youths (N=51), performed a threat-attention task during functional MRI acquisition. Task-related amygdala-based functional connectivity was assessed. Patients with and without imaging data (N=85) were then randomly assigned to receive CBT paired with either active or placebo ABMT. Clinical response was evaluated, and pretreatment amygdala-based connectivity profiles were compared among patients with varying levels of clinical response.

resultsCompared with the CBT plus placebo ABMT group, the CBT plus active ABMT group exhibited less severe anxiety after treatment. The patient and healthy comparison groups differed in amygdala-insula connectivity during the threat-attention task. Patients whose connectivity profiles were most different from those of the healthy comparison group exhibited the poorest response to treatment, particularly those who received CBT plus placebo ABMT.

conclusionsThe study provides evidence of enhanced clinical effects for patients receiving active ABMT. Moreover, ABMT appears to be most effective for patients with abnormal amygdala-insula connectivity. ABMT may target specific threat processes associated with dysfunctional amygdala-insula connectivity that are not targeted by CBT alone. This may explain the observation of enhanced clinical response to CBT plus active ABMT.

Indexed as

Attentional BiasAdolescentAmygdalaAnxiety DisordersArousalBehavior TherapyCerebral CortexChildCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMagnetic Resonance ImagingMaleNerve NetPrognosisAdolescentsAnxiety DisordersAttention Bias ModificationChild PsychiatryCognitive Neuroscience

Identifiers

PMID28407726
PMCPMC6343478
OpenAlexW2606438535

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.