Evidence map›Paper›PMID 28407646›Full record

ArticleSexually transmitted diseases2017

Assessing the Performance of 3 Human Immunodeficiency Virus Incidence Risk Scores in a Cohort of Black and White Men Who Have Sex With Men in the South.

Jeb Jones, Martin Hoenigl, Aaron J Siegler, Patrick S Sullivan, Susan Little, Eli Rosenberg

Erratum issuedAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Age-Specific Risk Scores Do Not Improve HIV-1 Prediction Among Women in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2020
    Article
  16. Review
  17. Validation of the San Diego Early Test Score for Early Human Immunodeficiency Virus Infection Among Amsterdam Men Who Have Sex With Men.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jeb JonesFrom the *Department of Epidemiology, Emory University, Atlanta, GA; †Division of Infectious Diseases, University of California, San Diego, San Diego, CA; and ‡Division of Pulmonology and Section of Infectious Diseases, Medical University of Graz, Graz, Austria.
Martin Hoenigl
Aaron J Siegler
Patrick S Sullivan
Susan Little
Eli Rosenberg

Funding

Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
Understanding substance use and incident HIV/STI among young black MSMR01DA038196 · NIDA · EMORY UNIVERSITY · PI ROSENBERG, ELI SAMUEL, SULLIVAN, PATRICK SEAN · 2014 to 2018
$3.2M
Efficacy of ART to Interrupt HIV Transmission NetworksR01MH100974 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2014 to 2018
$3.2M
Explaining Differences in HIV Prevalence and Incidence in Black and White MSMR01MH085600 · NIMH · EMORY UNIVERSITY · PI SULLIVAN, PATRICK SEAN · 2009 to 2013
$2.9M
Delay Discounting and HIV Sexual Risk Behavior in Men who Have Sex with MenF31AI122973 · NIAID · EMORY UNIVERSITY · PI JONES, JEB · 2016 to 2016
$40k
NIAID NIH HHS F31 AI122973NIAID NIH HHS R24 AI106039NIDA NIH HHS P50 DA026306NIDA NIH HHS R01 DA038196NIMH NIH HHS R01 MH085600NIMH NIH HHS R01 MH100974NIMH NIH HHS R25 MH081482
6 · The paper itself

Abstract

backgroundRisk scores have been developed to identify men at high risk of human immunodeficiency virus (HIV) seroconversion. These scores can be used to more efficiently allocate public health prevention resources, such as pre-exposure prophylaxis. However, the published scores were developed with data sets that comprise predominantly white men who have sex with men (MSM) collected several years prior and recruited from a limited geographic area. Thus, it is unclear how well these scores perform in men of different races or ethnicities or men in different geographic regions.

methodsWe assessed the predictive ability of 3 published scores to predict HIV seroconversion in a cohort of black and white MSM in Atlanta, GA. Questionnaire data from the baseline study visit were used to derive individual scores for each participant. We assessed the discriminatory ability of each risk score to predict HIV seroconversion over 2 years of follow-up.

resultsThe predictive ability of each score was low among all MSM and lower among black men compared to white men. Each score had lower sensitivity to predict seroconversion among black MSM compared to white MSM and low area under the curve values for the receiver operating characteristic curve indicating poor discriminatory ability.

conclusionsReliance on the currently available risk scores will result in misclassification of high proportions of MSM, especially black MSM, in terms of HIV risk, leading to missed opportunities for HIV prevention services.

Indexed as

AdolescentAdultArea Under CurveBlack or African AmericanCohort StudiesGeorgiaHIV InfectionsHIV SeropositivityHomosexuality, MaleHumansIncidenceMalePre-Exposure ProphylaxisRiskWhite PeopleYoung Adult

Identifiers

PMID28407646
PMCPMC5407317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.