ArticleCell host & microbe2017
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Registry-linked trialAbstract read
In one paragraph
Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03692611 (Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV), which is not on this map. Cited by 286 papers.
0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV
Who cites it
286 citing papers in PubMed.
- Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy.PLoS pathogens · 2025Trial
- Trial
- Natural killers blast HIV reservoir landscape.Nature immunology · 2026Article
- Intragenic transcription from defective HIV proviruses triggers interferon responses in myeloid cells.Journal of virology · 2026Article
- The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Early intervention, lasting impact: benefits of early antiretroviral therapy and implications for posttreatment control.Current opinion in HIV and AIDS · 2026Review
- Enhanced strand transfer and mismatch extension by HIV-1C reverse transcriptase promote sequence motif duplication.Journal of virology · 2026Article
- 5' leader defects drive persistent HIV-1 viremia on long-term ART.Nature communications · 2026Article
- HIV-1 virome profiling using HIV-PULSE to guide therapeutic and curative interventions.EBioMedicine · 2026Article
- Article
- The HIV reservoir landscape in elite controllers.Current opinion in HIV and AIDS · 2026Review
- HIV-1 infection does not confer intrinsic resistance to cell death induced by cytotoxic T lymphocytes.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional and Alternative Splicing Regulation of Autophagy and Vesicle Transport Pathways in Large Yellow Croaker Cells During Megalocytivirus Infection.Animals : an open access journal from MDPI · 2026Article
- Intragenic Transcription from Defective HIV Proviruses Triggers Interferon Responses in Myeloid Cells.bioRxiv : the preprint server for biology · 2026Article
- Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individuals.bioRxiv : the preprint server for biology · 2026Article
- Review: Systemic inflammation after stroke. Therapy and perspective.GeroScience · 2026Review
- Decoding HIV-1 Next Move Through Matrix Protein p17 Quasi-Species.MicrobiologyOpen · 2026Article
- Clonal dynamics of HIV-infected and uninfected T cells.EBioMedicine · 2026Article
- Undetectable unintegrated HIV-DNA in persons with HIV: frequency and determinants.BMC infectious diseases · 2026Article
- Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation.Journal of virology · 2026Article
226 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Ross A PollackDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
R Brad JonesDepartment of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Mihaela PerteaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Katherine M BrunerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Alyssa R MartinDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Allison S ThomasDepartment of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Adam A CapoferriDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA.
Subul A BegDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA.
Szu-Han HuangDepartment of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Sara KarandishDepartment of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Haiping HaoDeep Sequencing & Microarray Core, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Eitan Halper-StrombergUniversity of Colorado, Aurora, CO 80045, USA.
Patrick C YongIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Colin KovacsFaculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Maple Leaf Medical Clinic, Toronto, ON M5G 1K2, Canada.
Erika BenkoMaple Leaf Medical Clinic, Toronto, ON M5G 1K2, Canada.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA.
Ya-Chi HoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: yho10@jhmi.edu.
Funding
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MUsing NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LUCIW, PAUL · 2011 to 2015
$39.5MSWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6MViral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2011 to 2015
$29.5MBELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1MTraining Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7MThe District of Columbia Developmental Center for AIDS Research (DC D-CFAR)P30AI087714 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GREENBERG, ALAN EDWARD · 2010 to 2014
$8.4MHigh-throughput measurement and transcriptome analysis of the latent reservoir using HIV-1 RNA flow-FISHR21AI118402 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HO, YA-CHI · 2015 to 2016
$446kNIAID NIH HHS P30 AI087714NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI117970NIAID NIH HHS R21 AI118402NIAID NIH HHS U19 AI096109NIAID NIH HHS U19 AI096113NIAID NIH HHS UM1 AI126617NIGMS NIH HHS T32 GM008752
Abstract
Despite antiretroviral therapy, HIV-1 persists in memory CD4
Indexed as
Genetic VariationHIV-1HIV InfectionsHumansProvirusesT-Lymphocytes, Cytotoxicalternative splicingAPOBEC-mediated G-to-A hypermutationscell-associated HIV-1 RNAcold-target inhibitioncytotoxic T lymphocytesdefective HIV-1 provirusesdefective ribosomal productHIV-1 cureHIV-1 latent reservoirHIV-1 proviral landscape
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT03692611ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.