Evidence map›Paper›PMID 28407483›Full record

ArticleCell host & microbe2017

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Netusha Thevaranjan, Alicja Puchta, Christian Schulz, Avee Naidoo, J C Szamosi, Chris P Verschoor, Dessi Loukov, Louis P Schenck, Jennifer Jury, Kevin P Foley and 6 more

Erratum issuedAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 724 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
724citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

724 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Changes in theFrontiers in immunology · 2025
    Pooled it
  4. Effects ofNutrients · 2026
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  12. Reframing Alzheimer's Disease Through a Redox-Metabolic Framework.International journal of molecular sciences · 2026
    Review
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664 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Netusha ThevaranjanDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Alicja PuchtaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Christian SchulzDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Avee NaidooDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
J C SzamosiFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Chris P VerschoorDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Dessi LoukovDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Louis P SchenckMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Jennifer JuryFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Kevin P FoleyFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Jonathan D SchertzerFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Maggie J LarchéDepartment of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Donald J DavidsonUniversity of Edinburgh/MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Elena F VerdúFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Michael G SuretteMichael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Dawn M E BowdishDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address: bowdish@mcmaster.ca.

Funding

Medical Research Council G1002046
6 · The paper itself

Abstract

Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated. We find that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels. A higher proportion of germ-free mice live to 600 days than their conventional counterparts, and macrophages derived from aged germ-free mice maintain anti-microbial activity. Co-housing germ-free mice with old, but not young, conventionally raised mice increases pro-inflammatory cytokines in the blood. In tumor necrosis factor (TNF)-deficient mice, which are protected from age-associated inflammation, age-related microbiota changes are not observed. Furthermore, age-associated microbiota changes can be reversed by reducing TNF using anti-TNF therapy. These data suggest that aging-associated microbiota promote inflammation and that reversing these age-related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity.

Indexed as

PermeabilityAge FactorsAnimalsDysbiosisInflammationIntestinesMacrophagesMiceelderlyhost defenseimmunosenescenceinflamm-aginginflammationmacrophagemicrobiomemicrobiotaStreptococcus pneumoniae

Identifiers

PMID28407483
PMCPMC5392495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.