Evidence map›Paper›PMID 28407298›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Spatial Differences in the Distribution of Bone Between Femoral Neck and Trochanteric Fractures.

Aihong Yu, Julio Carballido-Gamio, Ling Wang, Thomas F Lang, Yongbin Su, Xinbao Wu, Manyi Wang, Jie Wei, Chen Yi, Xiaoguang Cheng

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Male-female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Secular trends of incidence and hospitalization cost of hip fracture in Tangshan, China.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  17. Article
  18. Article
  19. Heterogeneous Spatial and Strength Adaptation of the Proximal Femur to Physical Activity: A Within-Subject Controlled Cross-Sectional Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aihong YuDepartment of Radiology, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Julio Carballido-GamioDepartment of Radiology, University of Colorado Denver, Denver, CO, USA.
Ling WangDepartment of Radiology, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Thomas F LangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Yongbin SuDepartment of Radiology, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Xinbao WuDepartment of Traumatology and Orthopedic Surgery, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Manyi WangDepartment of Traumatology and Orthopedic Surgery, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Jie WeiDepartment of Traumatology and Orthopedic Surgery, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Chen YiDepartment of Traumatology and Orthopedic Surgery, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.
Xiaoguang ChengDepartment of Radiology, Beijing Jishuitan Hospital, 4th Medical College of Peking University, Beijing, China.

Funding

Multi-Parametric Spatial Assessment of Bone with HR-pQCTR01AR068456 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI BURGHARDT, ANDREW JOHN, CARBALLIDO-GAMIO, JULIO · 2016 to 2020
$1.4M
CT-based modeling to analyze variation in skeletal response to osteoporosis drugsR01AR064140 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEYAK, JOYCE H., LANG, THOMAS F · 2013 to 2016
$1.2M
NIAMS NIH HHS R01 AR064140NIAMS NIH HHS R01 AR068456
6 · The paper itself

Abstract

There is little knowledge about the spatial distribution differences in volumetric bone mineral density and cortical bone structure at the proximal femur between femoral neck fractures and trochanteric fractures. In this case-control study, a total of 93 women with fragility hip fractures, 72 with femoral neck fractures (mean ± SD age: 70.6 ± 12.7 years) and 21 with trochanteric fractures (75.6 ± 9.3 years), and 50 control subjects (63.7 ± 7.0 years) were included for the comparisons. Differences in the spatial distributions of volumetric bone mineral density, cortical bone thickness, cortical volumetric bone mineral density, and volumetric bone mineral density in a layer adjacent to the endosteal surface were investigated using voxel-based morphometry (VBM) and surface-based statistical parametric mapping (SPM). We compared these spatial distributions between controls and both types of fracture, and between the two types of fracture. Using VBM, we found spatially heterogeneous volumetric bone mineral density differences between control subjects and subjects with hip fracture that varied by fracture type. Interestingly, femoral neck fracture subjects, but not subjects with trochanteric fracture, showed significantly lower volumetric bone mineral density in the superior aspect of the femoral neck compared with controls. Using surface-based SPM, we found that compared with controls, both fracture types showed thinner cortices in regions in agreement with the type of fracture. Most outcomes of cortical and endocortical volumetric bone mineral density comparisons were consistent with VBM results. Our results suggest: 1) that the spatial distribution of trabecular volumetric bone mineral density might play a significant role in hip fracture; 2) that focal cortical bone thinning might be more relevant in femoral neck fractures; and 3) that areas of reduced cortical and endocortical volumetric bone mineral density might be more relevant for trochanteric fractures in Chinese women. © 2017 American Society for Bone and Mineral Research.

Indexed as

Bone DensityAgedAged, 80 and overFemaleFemoral Neck FracturesHip FracturesHumansMiddle AgedBONE MINERAL DENSITY (BMD)CORTICAL BONE THICKNESSFEMORAL NECK FRACTUREOSTEOPOROSISPROXIMAL FEMURQUANTITATIVE COMPUTED TOMOGRAPHY (QCT)STATISTICAL PARAMETRIC MAPPING (SPM)TROCHANTERIC FRACTUREVOXEL-BASED MORPHOMETRY (VBM)

Identifiers

PMID28407298
PMCPMC5550343

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.