ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Human infections with avian influenza A(H5) viruses with potential pandemic risk: 1997-2025.National science review · 2026Article
- Developing a Research Network of Early Warning Systems for Infectious Diseases Transmission Between China and Australia.China CDC weekly · 2024Article
- Risk Factors Contributing to Highly Pathogenic Avian Influenza H5N6 in China, 2014-2021: Based on a MaxEnt Model.Transboundary and emerging diseases · 2023Article
- Avian influenza overview September - December 2022.EFSA journal. European Food Safety Authority · 2023Article
- Avian influenza overview June - September 2022.EFSA journal. European Food Safety Authority · 2022Article
- Avian influenza overview March - June 2022.EFSA journal. European Food Safety Authority · 2022Article
- Avian influenza overview December 2021 - March 2022.EFSA journal. European Food Safety Authority · 2022Article
- Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice.Virologica Sinica · 2022Article
- Three Cases Infected with Avian Influenza A(H5N6) Virus - Chongqing Municipality, China, January-September, 2021.China CDC weekly · 2022Article
- Avian influenza overview May - September 2021.EFSA journal. European Food Safety Authority · 2022Article
- Avian influenza overview February - May 2021.EFSA journal. European Food Safety Authority · 2021Article
- Avian influenza overview September - December 2021.EFSA journal. European Food Safety Authority · 2021Article
- Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses.Emerging infectious diseases · 2021Article
- Avian influenza overview December 2020 - February 2021.EFSA journal. European Food Safety Authority · 2021Article
- Avian influenza overview August - December 2020.EFSA journal. European Food Safety Authority · 2020Article
- Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses.Antiviral research · 2020Article
- Avian influenza overview May - August 2020.EFSA journal. European Food Safety Authority · 2020Article
- Emerging Role of Mucosal Vaccine in Preventing Infection with Avian Influenza A Viruses.Viruses · 2020Review
- Article
- Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model.Antimicrobial agents and chemotherapy · 2020Article
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21 authors.
Funding
Abstract
backgroundSince 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics of laboratory-confirmed A(H5N6) cases were compared to A(H5N1) and A(H7N9) cases in mainland China.
methodsData on laboratory-confirmed H5N6, H5N1, and H7N9 cases identified in mainland China were analyzed to compare epidemiologic characteristics and clinical severity. Severity of confirmed H5N6, H5N1 and H7N9 cases was estimated based on the risk of severe outcomes in hospitalized cases.
resultsH5N6 cases were older than H5N1 cases with a higher prevalence of underlying medical conditions but younger than H7N9 cases. Epidemiological time-to-event distributions were similar among cases infected with the 3 viruses. In comparison to a fatality risk of 70% (30/43) for hospitalized H5N1 cases and 41% (319/782) for hospitalized H7N9 cases, 12 (75%) out of the 16 hospitalized H5N6 cases were fatal, and 15 (94%) required mechanical ventilation.
conclusionSimilar epidemiologic characteristics and high severity were observed in cases of H5N6 and H5N1 virus infection, whereas severity of H7N9 virus infections appeared lower. Continued surveillance of human infections with avian influenza A viruses remains an essential component of pandemic influenza preparedness.
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