ReviewEpidemiologic reviews2017
Early Life Exposures and Adult Cancer Risk.
Review in Epidemiologic reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Early and late-onset colorectal cancers: a case-case comparison of risk factors.Cancer causes & control : CCC · 2026Article
- Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.Cell · 2026Review
- Casting a long shadow: Exploring the link between childhood maltreatment and cancer in adulthood.PloS one · 2026Article
- Long-Term Cancer Incidence Trends in Korea (2001-2020): An Age-Period-Cohort and Joinpoint Analysis with a Focus on Younger Cohorts.Medicina (Kaunas, Lithuania) · 2025Article
- Examining the continuity of modifiable cancer-risk behaviors from youth into adulthood through prospective longitudinal studies: A scoping review.Social science & medicine (1982) · 2025Article
- Article
- Evaluating Clinical and Sociodemographic Risk for Symptom Burden Associated Interference With Daily Functioning in the Primary Brain Tumor Patient Population.Cancer medicine · 2025Observational
- Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring.Nature communications · 2025Article
- Advancing environmental epidemiologic methods to confront the cancer burden.American journal of epidemiology · 2025Article
- In Utero/Childhood/ Adolescence Exposure to Tobacco Smoke and Elderly-Onset Cataract: A Large Prospective Cohort Study.Translational vision science & technology · 2024Article
- Associations between child eating behaviors with eating patterns and diet quality in preschool-aged children.Appetite · 2024Article
- Analyses of oxidative DNA damage among coal vendors via single cell gel electrophoresis and quantification of 8-hydroxy-2'-deoxyguanosine.Molecular and cellular biochemistry · 2024Article
- Exploring Cancer Incidence Trends by Age and Sex Among 14.14 Million Individuals in China From 2007 to 2021: Population-Based Study.JMIR public health and surveillance · 2024Article
- The association between being breastfed in infancy and risks of cancer in adulthood-a UK Biobank study.BJC reports · 2024Article
- Residential mobility and liver cancer risk: findings from a prospective cohort study in Chinese women.BMC public health · 2024Article
- Increasing Annual Cancer Incidence in Patients Age 20-49 Years: A Real-Data Study.JCO global oncology · 2024Article
- Changing epidemiology of colorectal cancer - birth cohort effects and emerging risk factors.Nature reviews. Gastroenterology & hepatology · 2024Review
- Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2).International journal of epidemiology · 2023Article
- Alcohol intake and the risk of epithelial ovarian cancer.Cancer causes & control : CCC · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Very little is known about the influence of early life exposures on adult cancer risk. The purpose of this narrative review was to summarize the epidemiologic evidence relating early life tobacco use, obesity, diet, and physical activity to adult cancer risk; describe relevant theoretical frameworks and methodological strategies for studying early life exposures; and discuss policies and research initiatives focused on early life. Our findings suggest that in utero exposures may indirectly influence cancer risk by modifying biological pathways associated with carcinogenesis; however, more research is needed to firmly establish these associations. Initiation of exposures during childhood and adolescence may impact cancer risk by increasing duration and lifetime exposure to carcinogens and/or by acting during critical developmental periods. To expand the evidence base, we encourage the use of life course frameworks, causal inference methods such as Mendelian randomization, and statistical approaches such as group-based trajectory modeling in future studies. Further, we emphasize the need for objective exposure biomarkers and valid surrogate endpoints to reduce misclassification. With the exception of tobacco use, there is insufficient evidence to support the development of new cancer prevention policies; however, we highlight existing policies that may reduce the burden of these modifiable risk factors in early life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.