ArticlePloS one2017
Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Burden and determinants of puerperal sepsis in Ethiopia: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- The aetiology and antimicrobial resistance of bacterial maternal infections in Sub-Saharan Africa-a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Burden of Antimicrobial Resistance Among Women with Post-Partum Infections in Low-Middle Income Countries: A Systematic Review.Journal of epidemiology and global health · 2024Pooled it
- Understanding the Effect of a Healthcare Provider-Led Family Planning Support Intervention on Contraception use and Pregnancy Desires among Postpartum Women Living with HIV in Southwestern Uganda.AIDS and behavior · 2022Trial
- Multi-drug resistant surgical site infections following caesarean delivery: a prospective observational study from urban Uganda.BMC women's health · 2025Observational
- Outcomes of a honey and olive oil-based dressing material on wounds of women that have had a caesarean section in south-western Uganda.International wound journal · 2024Article
- Impact of postpartum maternal fever or hypothermia on newborn and early infant illness and death in Southwestern Uganda.BMC pregnancy and childbirth · 2024Article
- Peripartum Infections: A Position Statement of the Indian Society of Critical Care Medicine.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Characterization of Antibiotic Resistance in Select Tertiary Hospitals in Uganda: An Evaluation of 2020 to 2023 Routine Surveillance Data.Tropical medicine and infectious disease · 2024Article
- The epidemiology and risk factors for postnatal complications among postpartum women and newborns in southwestern Uganda: A prospective cohort study.PLOS global public health · 2024Article
- Risk factors and genetic characteristics of the carriage of hypervirulent and carbapenem-resistantFrontiers in microbiology · 2024Article
- In vitro Antibacterial Activities of Selected Medicinal Plants Used by Traditional Healers for Treating Urinary Tract Infection in Haramaya District, Eastern Ethiopia.Infection and drug resistance · 2023Article
- Antimicrobial stewardship: Attitudes and practices of healthcare providers in selected health facilities in Uganda.PloS one · 2022Article
- Article
- Implementation of the World Health Organization Global Antimicrobial Resistance Surveillance System in Uganda, 2015-2020: Mixed-Methods Study Using National Surveillance Data.JMIR public health and surveillance · 2021Article
- Overuse of antibiotics in maternity and neonatal wards, a descriptive report from public hospitals in Dar es Salaam, Tanzania.Antimicrobial resistance and infection control · 2021Article
- Antibiotic resistance profiles and population structure of disease-associatedMicrobiology (Reading, England) · 2021Article
- Surgical Site Infection Following Caesarean Section byMicroorganisms · 2021Article
- Surgical Site Infections and Antimicrobial Resistance After Cesarean Section Delivery in Rural Rwanda.Annals of global health · 2021Article
- Clinical and microbiological characterization of sepsis and evaluation of sepsis scores.PloS one · 2021Observational
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionPuerperal sepsis causes 10% of maternal deaths in Africa, but prospective studies on incidence, microbiology and antimicrobial resistance are lacking.
methodsWe performed a prospective cohort study of 4,231 Ugandan women presenting to a regional referral hospital for delivery or postpartum care, measured vital signs after delivery, performed structured physical exam, symptom questionnaire, and microbiologic evaluation of febrile and hypothermic women. Malaria rapid diagnostic testing, blood and urine cultures were performed aseptically and processed at Epicentre Mbarara Research Centre. Antimicrobial susceptibility and breakpoints were determined using disk diffusion per EUCAST standards. Hospital diagnoses, treatments and outcomes were abstracted from patient charts.
resultsMean age was 25 years, 12% were HIV-infected, and 50% had cesarean deliveries. Approximately 5% (205/4176) with ≥1 temperature measurement recorded developed postpartum fever or hypothermia; blood and urine samples were collected from 174 (85%), and 17 others were evaluated clinically. Eighty-four (48%) had at least one confirmed source of infection: 39% (76/193) clinical postpartum endometritis, 14% (25/174) urinary tract infection (UTI), 3% (5/174) bloodstream infection. Another 3% (5/174) had malaria. Overall, 30/174 (17%) had positive blood or urine cultures, and Acinetobacter species were the most common bacteria isolated. Of 25 Gram-negatives isolated, 20 (80%) were multidrug-resistant and cefepime non-susceptible.
conclusionsFor women in rural Uganda with postpartum fever, we found a high rate of antibiotic resistance among cultured urinary and bloodstream infections, including cephalosporin-resistant Acinetobacter species. Increasing availability of microbiology testing to inform appropriate antibiotic use, development of antimicrobial stewardship programs, and strengthening infection control practices should be high priorities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.