ReviewGenetics in medicine : official journal of the American College of Medical Genetics2017
Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.
Review in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Who cites it
32 citing papers in PubMed.
- Pragmatic Trials in Genomic Medicine: The Integrating Pharmacogenetics In Clinical Care (I-PICC) Study.Clinical and translational science · 2020Trial
- Article
- Advances in predicting breast cancer driver mutations: Tools for precision oncology (Review).International journal of molecular medicine · 2025Review
- Readiness to Accept Genetic Testing for Personalized Medicine: Survey Findings on the Role of Socio-Demographic Characteristics, Health Vulnerabilities, Perceived Genetic Risk and Personality Factors.Journal of personalized medicine · 2022Article
- Evaluating genetic and genomic tests for heritable conditions in Australia: lessons learnt from health technology assessments.Journal of community genetics · 2022Article
- Current state and future directions of genomic medicine in aortic dissection: A path to prevention and personalized care.Seminars in vascular surgery · 2022Review
- Quality of life drives patients' preferences for secondary findings from genomic sequencing.European journal of human genetics : EJHG · 2020Article
- Using the Delphi method to identify clinicians' perceived importance of pediatric exome sequencing results.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- The Importance of the Tumor Microenvironment and Hypoxia in Delivering a Precision Medicine Approach to Veterinary Oncology.Frontiers in veterinary science · 2020Review
- Leveraging implementation science to improve implementation outcomes in precision medicine.American journal of translational research · 2020Review
- Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests.Journal of genetic counseling · 2019Article
- Rapid Whole Genome Sequencing Has Clinical Utility in Children in the PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network.JCO clinical cancer informatics · 2019Article
- Building evidence and measuring clinical outcomes for genomic medicine.Lancet (London, England) · 2019Review
- Personalized Medicine Implementation with Non-traditional Data Sources: A Conceptual Framework and Survey of the Literature.Yearbook of medical informatics · 2019Review
- Article
- Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Genome-wide sequencing in acutely ill infants: genomic medicine's critical application?Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Infectious Disease Risk in Dialysis Patients: A Transdisciplinary Approach.Canadian journal of kidney health and disease · 2019Review
- Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs.Healthcare (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Comparative effectiveness research (CER) in genomic medicine (GM) measures the clinical utility of using genomic information to guide clinical care in comparison to appropriate alternatives. We summarized findings of high-quality systematic reviews that compared the analytic and clinical validity and clinical utility of GM tests. We focused on clinical utility findings to summarize CER-derived evidence about GM and identify evidence gaps and future research needs. We abstracted key elements of study design, GM interventions, results, and study quality ratings from 21 systematic reviews published in 2010 through 2015. More than half (N = 13) of the reviews were of cancer-related tests. All reviews identified potentially important clinical applications of the GM interventions, but most had significant methodological weaknesses that largely precluded any conclusions about clinical utility. Twelve reviews discussed the importance of patient-centered outcomes, although few described evidence about the impact of genomic medicine on these outcomes. In summary, we found a very limited body of evidence about the effect of using genomic tests on health outcomes and many evidence gaps for CER to address.Genet Med advance online publication 13 April 2017.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.