ArticleScientific reports2017
Anchored but not internalized: shape dependent endocytosis of nanodiamond.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Investigating size and surface modification to optimise the delivery of nanodiamonds to brain glial cells.Discover nano · 2025Article
- Effects of diamond nanoparticle surface composition and the spScientific reports · 2025Article
- Zwitterionic Dipeptide Surface Functionalization of Detonation Nanodiamond for Enhanced Control in Biological Environments.Angewandte Chemie (International ed. in English) · 2025Article
- Cell-particles interaction - selective uptake and transport of microdiamonds.Communications biology · 2024Article
- Silicon Vacancy in Boron-Doped Nanodiamonds for Optical Temperature Sensing.Materials (Basel, Switzerland) · 2023Article
- Cellular Alterations in Carbohydrate and Lipid Metabolism Due to Interactions with Nanomaterials.Journal of functional biomaterials · 2023Review
- Intracellular Relaxometry, Challenges, and Future Directions.ACS central science · 2022Review
- Targeting cell surface glycans with lectin-coated fluorescent nanodiamonds.Nanoscale advances · 2022Article
- Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking.Nano today · 2021Review
- Article
- The Influence of Nanoparticle Properties on Oral Bioavailability of Drugs.International journal of nanomedicine · 2020Review
- Shape Matters: Comprehensive Analysis of Star-Shaped Lipid Nanoparticles.Frontiers in pharmacology · 2020Article
- Biocompatibility studies of fluorescent diamond particles-(NV)~800nm (part V): in vitro kinetics and in vivo localization in rat liver following long-term exposure.International journal of nanomedicine · 2019Article
- Fluorescent Nanodiamond Applications for Cellular Process Sensing and Cell Tracking.Micromachines · 2018Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount. Molecular dynamics simulation and continuum modelling results suggest that the observed difference in the anchoring of round and prickly NDs likely results from the reduced contact surface area with the cell membrane of the former, while the energy penalty associated with membrane curvature generation, which is lower for a round ND, may explain its higher probability of the subsequent internalization.
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