ArticleScientific reports2017
Exploring the significance of morphological diversity for cerebellar granule cell excitability.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Structured sampling of molecularly classified mossy fiber inputs by cerebellar granule cells.Frontiers in computational neuroscience · 2026Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Developmental timing-dependent organization of synaptic connections between mossy fibers and granule cells in the cerebellum.Communications biology · 2023Article
- Temporal Diffusion Ratio (TDR) for imaging restricted diffusion: Optimisation and pre-clinical demonstration.NeuroImage · 2023Article
- Machine learning classification reveals robust morphometric biomarker of glial and neuronal arbors.Journal of neuroscience research · 2023Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Compensatory variability in network parameters enhances memory performance in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Projection-dependent heterogeneity of cerebellar granule cell calcium responses.Molecular brain · 2021Article
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Granular layEr Simulator: Design and Multi-GPU Simulation of the Cerebellar Granular Layer.Frontiers in computational neuroscience · 2021Article
- Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.Communications biology · 2020Article
- Pycabnn: Efficient and Extensible Software to Construct an Anatomical Basis for a Physiologically Realistic Neural Network Model.Frontiers in neuroinformatics · 2020Article
- Complex Electroresponsive Dynamics in Olivocerebellar Neurons Represented With Extended-Generalized Leaky Integrate and Fire Models.Frontiers in computational neuroscience · 2019Article
- Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.Scientific reports · 2018Article
- Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex.Frontiers in cellular neuroscience · 2017Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
The relatively simple and compact morphology of cerebellar granule cells (CGCs) has led to the view that heterogeneity in CGC shape has negligible impact upon the integration of mossy fibre (MF) information. Following electrophysiological recording, 3D models were constructed from high-resolution imaging data to identify morphological features that could influence the coding of MF input patterns by adult CGCs. Quantification of MF and CGC morphology provided evidence that CGCs could be connected to the multiple rosettes that arise from a single MF input. Predictions from our computational models propose that MF inputs could be more densely encoded within the CGC layer than previous models suggest. Moreover, those MF signals arriving onto the dendrite closest to the axon will generate greater CGC excitation. However, the impact of this morphological variability on MF input selectivity will be attenuated by high levels of CGC inhibition providing further flexibility to the MF → CGC pathway. These features could be particularly important when considering the integration of multimodal MF sensory input by individual CGCs.
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