Evidence map›Paper›PMID 28406139›Full record

ArticleScientific reports2017

T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.

Arun K Kannan, Sonia Mohinta, Weishan Huang, Lu Huang, Nicholas Koylass, Judith A Appleton, Avery August

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arun K KannanDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Sonia MohintaDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Weishan HuangDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Lu HuangDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Nicholas KoylassDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Judith A AppletonDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Avery AugustDepartment of Microbiology &Immunology, Cornell University, Ithaca, NY, 14853, USA.
Cornell University · USAbbVie (United States) · US

Funding

Itk mediated tuning of CD8+ memory T cell developmentR01AI120701 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2016 to 2019
$1.5M
Selective Aryl Hydrocarbon Receptor Modulators and T cell Effector FunctionR21AI108958 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2014 to 2015
$430k
Controlling Th17 cells and responses in airway inflammation by tyrosine kinase ItkR21AI126814 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2016 to 2017
$426k
NIAID NIH HHS HHSN272201300006CNIAID NIH HHS R01 AI120701NIAID NIH HHS R21 AI108958NIAID NIH HHS R21 AI126814
6 · The paper itself

Abstract

Th1, Th2, Th9 and Th17 cells are conventional CD4

Indexed as

AnimalsInterferon-gammaInterleukin-4Mice, Inbred C57BLMice, KnockoutProtein-Tyrosine KinasesReceptors, Antigen, T-CellSignal TransductionT-bet Transcription FactorT-Box Domain ProteinsTh1 CellsTh2 CellsThymocytesTrichinella spiralisTrichinellosisemt protein-tyrosine kinaseInterferon-gammaInterleukin-4Protein-Tyrosine KinasesReceptors, Antigen, T-CellT-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID28406139
PMCPMC5390256
OpenAlexW2607006651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.