Evidence map›Paper›PMID 28406012›Full record

ArticleACS applied materials & interfaces2017

Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells.

Wooram Park, Andrew C Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R Harris, Andrew C Larson, Dong-Hyun Kim

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
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  5. Cold and hot tumors: from molecular mechanisms to targeted therapy.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wooram ParkDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.ORCID http://orcid.org/0000-0002-4614-0530
Andrew C GordonDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Soojeong ChoDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Xiaoke HuangDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Kathleen R HarrisDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Andrew C LarsonDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Dong-Hyun KimDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.ORCID http://orcid.org/0000-0001-6815-3319

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver TumorsR01CA181658 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LARSON, ANDREW CHRISTIAN · 2015 to 2019
$2.1M
Magnetic Nanocomposites for Catheter-Directed Drug Delivery to Liver TumorsR21EB017986 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DONG-HYUN · 2014 to 2015
$425k
Magnetic Micelles for Catheter-Directed Sorafenib Delivery to Liver TumorsR21CA185274 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DONG-HYUN · 2015 to 2016
$367k
Targeted Transcatheter Magneto-Mechanical Therapy for Hepatocellular CarcinomaR21CA173491 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, DONG-HYUN · 2013 to 2014
$364k
NCI NIH HHS R01 CA181658NCI NIH HHS R21 CA173491NCI NIH HHS R21 CA185274NIBIB NIH HHS R21 EB017986NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T

Indexed as

MicrospheresAnimalsInterferon-gammaKiller Cells, NaturalLiver NeoplasmsMagnetic Resonance ImagingRabbitsInterferon-gammaand image-guided therapycancer immunotherapyinterferon-gamma (IFN-γ)microspheresnatural killer (NK) cells infiltration

Identifiers

PMID28406012
PMCPMC5719880

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.