Evidence map›Paper›PMID 28405865›Full record

ArticleJournal of assisted reproduction and genetics2017

Involvement of 17β-hydroxysteroid dehydrogenase type gene 1 937 A>G polymorphism in infertility in Polish Caucasian women with endometriosis.

Maciej Osiński, Adrianna Mostowska, Przemyslaw Wirstlein, Jana Skrzypczak, Paweł Piotr Jagodziński, Malgorzata Szczepańska

Open access · hybridAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Review
  3. Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019
    Review
  4. Endometriosis andExperimental and therapeutic medicine · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maciej OsińskiDepartment of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
Adrianna MostowskaDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
Przemyslaw WirstleinDepartment of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
Jana SkrzypczakDepartment of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
Paweł Piotr JagodzińskiDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
Malgorzata SzczepańskaDepartment of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland. mal.gin@poczta.fm.
Poznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEndometriosis is considered to be an estrogen-related chronic inflammatory disease. The 17β-hydroxysteroid dehydrogenase 1 (HSD17B1) converts estrone to 17β estradiol. The role of HSD17B1 937 A>G (rs605059) single nucleotide polymorphism (SNP) in development of endometriosis is still disputable. This study evaluated the association of the HSD17B1 937 A>G (rs605059) SNP with infertile women affected by endometriosis from Polish Caucasian population.

methodsThe genotyping of cases (n = 290) and fertile women (n = 410) was conducted by high-resolution melting curve analysis.

resultsStatistical analysis demonstrated that the HSD17B1 937 A>G SNP is associated with endometriosis in stages I and II. The p

conclusionOur genetic study demonstrated HSD17B1 937 G variant as a risk factor for infertility in women with stage I and II endometriosis in Polish Caucasian patients.

Indexed as

Genetic Predisposition to DiseaseAdultEndometriosisEstradiol DehydrogenasesEstrogensFemaleGenotypeHumansInfertility, FemalePolandPolymorphism, Single NucleotideRisk FactorsEstradiol DehydrogenasesEstrogensHSD17B1 protein, humanEndometriosisHSD17B1Polymorphism

Identifiers

PMID28405865
PMCPMC5445048
OpenAlexW2606788951

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.