Evidence map›Paper›PMID 28405721›Full record

ReviewCellular and molecular life sciences : CMLS2017

Genome editing: a robust technology for human stem cells.

Arun Pandian Chandrasekaran, Minjung Song, Suresh Ramakrishna

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Highly Efficient Genome Engineering inFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arun Pandian ChandrasekaranGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Republic of Korea.
Minjung SongDivision of Bioindustry, Department of Food Biotechnology, College of Medical and Life Science, Silla University, Seoul, Republic of Korea. songmj@silla.ac.kr.
Suresh RamakrishnaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Republic of Korea. suri28@hanyang.ac.kr.ORCID 0000-0002-4038-1085
Hanyang University · KRSilla University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells.

Indexed as

Gene EditingAdenomatous Polyposis Coli ProteinCRISPR-Cas SystemsEndodeoxyribonucleasesGenome, HumanHumansras ProteinsReceptors, CCR5Stem CellsTranscription Activator-Like Effector NucleasesTumor Suppressor Protein p53Adenomatous Polyposis Coli ProteinEndodeoxyribonucleasesras ProteinsReceptors, CCR5Transcription Activator-Like Effector NucleasesTumor Suppressor Protein p53Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated systemEmbryonic stem cellsInduced pluripotent stem cellsTranscription activator-like effector nucleasesZinc finger nucleases

Identifiers

PMID28405721
PMCPMC11107609
OpenAlexW2606525939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.