Evidence map›Paper›PMID 28405625›Full record

ArticleJCI insight2017

Resistance to hypertension mediated by intercalated cells of the collecting duct.

Johannes Stegbauer, Daian Chen, Marcela Herrera, Matthew A Sparks, Ting Yang, Eva Königshausen, Susan B Gurley, Thomas M Coffman

Open access · goldAbstract read
In one paragraph

Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. NaHypertension (Dallas, Tex. : 1979) · 2022
    Article
  7. Review
  8. Journal of the American Society of Nephrology : JASN · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Johannes StegbauerDivision of Nephrology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.
Daian ChenDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Marcela HerreraDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Matthew A SparksDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Ting YangDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Eva KönigshausenDivision of Nephrology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.
Susan B GurleyDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Thomas M CoffmanDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.
Duke University · USDüsseldorf University Hospital · DE

Funding

Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI FOSTER, MARY H., SVETKEY, LAURA P · 2012 to 2016
$5.9M
Paracrine Control of Blood Pressure by Renal Intercalated CellsR01DK105049 · NIDDK · DUKE UNIVERSITY · PI COFFMAN, THOMAS M · 2015 to 2019
$1.8M
AT1 Angiotensin Receptors in the Renal Circulation Control Blood PressureIK2BX002240 · VA · DURHAM VA MEDICAL CENTER · PI SPARKS, MATTHEW AARON · 2014 to 2018
–
BLRD VA IK2 BX002240NIDDK NIH HHS P30 DK096493NIDDK NIH HHS R01 DK105049
6 · The paper itself

Abstract

The renal collecting duct (CD), as the terminal segment of the nephron, is responsible for the final adjustments to the amount of sodium excreted in urine. While angiotensin II modulates reabsorptive functions of the CD, the contribution of these actions to physiological homeostasis is not clear. To examine this question, we generated mice with cell-specific deletion of AT

Indexed as

Angiotensin IIAnimalsBlood PressureCyclooxygenase 2Cyclooxygenase 2 InhibitorsDisease Models, AnimalHypertensionKidney Tubules, CollectingMiceMice, KnockoutReceptor, Angiotensin, Type 1Angiotensin IICyclooxygenase 2Cyclooxygenase 2 InhibitorsPtgs2 protein, mouseReceptor, Angiotensin, Type 1

Identifiers

PMID28405625
PMCPMC5374064
OpenAlexW2604221569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.