Evidence map›Paper›PMID 28405611›Full record

Trial reportJCI insight2017

Long-term follow-up of a randomized AAV2-

Martin Niethammer, Chris C Tang, Peter A LeWitt, Ali R Rezai, Maureen A Leehey, Steven G Ojemann, Alice W Flaherty, Emad N Eskandar, Sandra K Kostyk, Atom Sarkar and 12 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04228172 (Genotypic Influences on Network Progression in Parkinson's Disease), which is not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04228172 active not recruitingnot on this mapstarted 2020, after this paper: background citation

Genotypic Influences on Network Progression in Parkinson's Disease

TypeobservationalSponsorNorthwell HealthRan2020 to 2026Enrolled32ConditionsParkinson's DiseaseArmsDNA/GeneticTesting, FDG PET scan, MRI scan, Clinical and neuropsychological assessments
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Genetic therapies for neurological diseases.Pharmacological reviews · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. From lab bench to hope: a review of gene therapies in clinical trials for Parkinson's disease and challenges.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  17. Review
  18. Review
  19. Review
  20. Neurosurgical gene therapy for central nervous system diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 1 country.

Martin NiethammerCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Chris C TangCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Peter A LeWittParkinson's Disease and Movement Disorders Program, Henry Ford Hospital, West Bloomfield, Michigan, USA; Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Ali R RezaiDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Maureen A LeeheyDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Steven G OjemannDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Alice W FlahertyDepartment of Neurology and.
Emad N EskandarDepartment of Neurology and.
Sandra K KostykDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Atom SarkarDepartment of Neurosurgery, Geisinger Health System, Danville, Pennsylvania, USA.
Mustafa S SiddiquiDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Stephen B TatterDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jason M SchwalbMovement Disorder & Comprehensive Epilepsy Centers, Henry Ford Medical Group, West Bloomfield, Michigan, USA.
Kathleen L PostonDepartment of Neurology and Neurological Sciences and.
Jaimie M HendersonDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Roger M KurlanNeurology, The Center for Neurological and Neurodevelopmental Health, Voorhees, New Jersey, USA.
Irene H RichardDepartment of Neurology and Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Christine V SapanAsana Medical Inc., Miami Lakes, Florida, USA.
David EidelbergCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Matthew J DuringDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Michael G KaplittDepartment of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA.
Andrew FeiginCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Feinstein Institute for Medical Research · USNeurological Surgery · USStanford University · USUniversity of Colorado Denver · USWake Forest University · USComprehensive Cardiovascular · USCornell University · USFlorida Gateway College · USGeisinger Health System · USHenry Ford Hospital · USMassachusetts General Hospital · USNeuroDevelopment Center · USUniversity of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedDependovirusDouble-Blind MethodFemaleFollow-Up StudiesGenetic TherapyGene Transfer TechniquesGlutamate DecarboxylaseHumansMaleMiddle AgedParkinson DiseaseParvovirinaePositron-Emission TomographySubthalamic NucleusGlutamate Decarboxylase

Identifiers

PMID28405611
PMCPMC5374069
OpenAlexW2604153654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.