ArticleTransplantation direct2017
Longitudinal Analysis of the Intestinal Microbiota in Liver Transplantation.
Article in Transplantation direct, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Who cites it
50 citing papers in PubMed, 79 citations in OpenAlex.
- Gut microbiota and metabolic pathway profiles in infected and non-infected heart transplant patients before and after surgery.Scientific reports · 2026Article
- Longitudinal analysis of gut bacterial and fungal dynamics after solid organ transplantation.BMC microbiology · 2026Article
- Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients.PloS one · 2026Article
- Gut microbiome and metabolite signatures for predicting acute kidney transplant rejection: a prospective study.Scientific reports · 2025Article
- Gut microbiome and metabolome profiles in renal allograft rejection from multiomics integration.mSystems · 2025Article
- Ocular Surface Microbiota and Corneal Transplant Outcome: Is There a Link?Biomedicines · 2025Article
- The gut microbiota in liver transplantation recipients during the perioperative and postoperative recovery period.Frontiers in microbiology · 2025Article
- Harnessing the microbiome to improve clinical outcomes for cancer, transplant, and immunocompromised patients in the intensive care unit (ICU).Frontiers in cellular and infection microbiology · 2025Review
- Gut Microbial Dysbiosis and Implications in Solid Organ Transplantation.Biomedicines · 2024Review
- Article
- Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes.Hematology reports · 2024Review
- The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations.Infection · 2024Review
- Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation.World journal of transplantation · 2024Review
- The Microbiome and Pediatric Transplantation.Journal of the Pediatric Infectious Diseases Society · 2024Review
- An urgent need for longitudinal microbiome profiling coupled with machine learning interventions.Frontiers in microbiology · 2024Article
- Solid organ transplantation and gut microbiota: a review of the potential immunomodulatory properties of short-chain fatty acids in graft maintenance.Frontiers in cellular and infection microbiology · 2024Review
- Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects.Frontiers in immunology · 2024Review
- Review
- Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study.Signal transduction and targeted therapy · 2023Article
- Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing evidence suggests that the intestinal microbiota plays an important role in liver diseases. However, the dynamics of the intestinal microbiota during liver transplantation (LT) and its potential role in clinical course remain unknown.
methodsWe prospectively analyzed the intestinal microbiota of 38 patients who underwent LT in Kyoto University Hospital. We characterized the microbial compositions of fecal specimens from LT patients using a metagenomics approach by an Illumina MiSeq platform. We analyzed the diversity of microbiota sequentially from pretransplantation until 2 months after LT and also compared the microbiota during an episode of acute cellular rejection (ACR) and bloodstream infections (BSI) to the microbial composition of time-matched fecal specimens obtained from patients who did not experience ACR or BSI, respectively.
resultsThree hundred twenty fecal specimens were analyzed. Dynamic changes were observed in the microbial composition of LT recipients during the perioperative period. Over the course of LT, the mean diversity index decreased during the first 3 weeks after LT and gradually increased during our observation period. The loss of intestinal microbiota diversity was associated with high Child-Pugh scores, high model for end-stage liver disease scores, ACR, and BSI. At the family level,
conclusionsThe microbiota of LT patients was associated with the severity of liver diseases and the presence of ACR and BSI. These results lay the groundwork for more comprehensive investigations of microbiota characteristics to identify diagnostic markers for transplant health and to guide intervention strategies to improve transplant outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.