Evidence map›Paper›PMID 28405524›Full record

ArticleOncoimmunology

Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.

Kellsye Paula L Fabian, Nina Chi-Sabins, Jennifer L Taylor, Ronald Fecek, Aliyah Weinstein, Walter J Storkus

Abstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. DLK1: a novel therapeutic target in cancer.Endocrine-related cancer · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. The Emerging Roles of Pericytes in Modulating Tumor Microenvironment.Frontiers in cell and developmental biology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kellsye Paula L FabianDepartment of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Nina Chi-SabinsDepartment of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Jennifer L TaylorDepartment of Dermatology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Ronald FecekDepartment of Dermatology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Aliyah WeinsteinDepartment of Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA.
Walter J StorkusDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; The University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Combinational Immunotherapy Targeting the Melanoma-Associated VasculatureR01CA169118 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STORKUS, WALTER J. · 2012 to 2016
$2.1M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA169118
6 · The paper itself

Abstract

When compared with vascular cells in normal tissues, pericytes and vascular endothelial cells (VEC) in tumor blood vessels exhibit altered morphology and epigenetic programming that leads to the expression of unique antigens that allow for differential recognition by CD8

Indexed as

CD8+ T cellsDCimmunotherapypericytetumorvaccinevascular endothelial cellvascular normalization

Identifiers

PMID28405524
PMCPMC5384378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.