ArticleRoyal Society open science2017
Mechanisms of vortices termination in the cardiac muscle.
Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing.Frontiers in network physiology · 2024Article
- Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm.Frontiers in network physiology · 2023Article
- Non-monotonous dose response function of the termination of spiral wave chaos.Scientific reports · 2022Article
- Overdrive pacing of spiral waves in a model of human ventricular tissue.Scientific reports · 2020Article
- Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study.Journal of atrial fibrillation · 2019Article
- Termination of Scroll Waves by Surface Impacts.Physical review letters · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation.
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Registered trials
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