Evidence map›Paper›PMID 28405363›Full record

ArticleRoyal Society open science2017

An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor.

K E Dunn, M C Leake, A J M Wollman, M A Trefzer, S Johnson, A M Tyrrell

Abstract read
In one paragraph

Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Assembly-Energetics-Control (AEC) Design Framework for Rotary DNA Nanomachines.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

K E DunnDepartment of Electronics , University of York , Heslington, York YO10 5DD, UK.ORCID 0000-0002-5068-4354
M C LeakeBiological Physical Sciences Institute, Departments of Physics and Biology , University of York , Heslington, York YO10 5DD, UK.
A J M WollmanBiological Physical Sciences Institute, Departments of Physics and Biology , University of York , Heslington, York YO10 5DD, UK.
M A TrefzerDepartment of Electronics , University of York , Heslington, York YO10 5DD, UK.
S JohnsonDepartment of Electronics , University of York , Heslington, York YO10 5DD, UK.
A M TyrrellDepartment of Electronics , University of York , Heslington, York YO10 5DD, UK.

Funding

Medical Research Council MR/K01580X/1
6 · The paper itself

Abstract

DNA has been used to construct a wide variety of nanoscale molecular devices. Inspiration for such synthetic molecular machines is frequently drawn from protein motors, which are naturally occurring and ubiquitous. However, despite the fact that rotary motors such as ATP synthase and the bacterial flagellar motor play extremely important roles in nature, very few rotary devices have been constructed using DNA. This paper describes an experimental study of the putative mechanism of a rotary DNA nanomotor, which is based on strand displacement, the phenomenon that powers many synthetic linear DNA motors. Unlike other examples of rotary DNA machines, the device described here is designed to be capable of autonomous operation after it is triggered. The experimental results are consistent with operation of the motor as expected, and future work on an enhanced motor design may allow rotation to be observed at the single-molecule level. The rotary motor concept presented here has potential applications in molecular processing, DNA computing, biosensing and photonics.

Indexed as

DNA nanotechnologymolecular machinerotary motorstrand displacement

Identifiers

PMID28405363
PMCPMC5383820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.