ArticleUnited European gastroenterology journal2017
Iron overload correlates with serum liver fibrotic markers and liver dysfunction: Potential new methods to predict iron overload-related liver fibrosis in thalassemia patients.
Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Association between Transfusion-Related Iron Overload and Liver Fibrosis in Survivors of Pediatric Leukemia: A Cross-Sectional Study.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Article
- Iron overload status in patients with non-transfusion-dependent thalassemia in China.Therapeutic advances in hematology · 2022Article
- Novel genetic therapeutic approaches for modulating the severity of β-thalassemia (Review).Biomedical reports · 2020Review
- Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron.Heliyon · 2020Article
- Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics.Molecules (Basel, Switzerland) · 2020Article
- Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion.PloS one · 2020Observational
- Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload.BioMed research international · 2019Article
- Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEarly detection of liver fibrosis in thalassemia patients and rapid initiation of treatment to interfere with its progression are extremely important.
objectiveThis study aimed to find a sensitive, easy-to-detect and noninvasive method other than liver biopsy for early detection of liver fibrosis in thalassemia patients.
methodsA total of 244 Chinese Thalassemia patients with non-transfusion-dependent thalassemia (NTDT,
resultsSerum C IV, PIIINPC and HA were significantly elevated in Chinese patients with NTDT and further elevated in TM patients. Moreover, C IV, PIIINPC and HA were also positively correlated to serum ferritin and liver iron concentration and further elevated during the progression to multi-organ damage in NTDT patients. Finally, serum ferritin and liver iron concentration were significantly correlated with liver dysfunction determined by AST and ALT.
conclusionTaken together, our results indicate that monitoring serum C IV, PIIINPC and HA is a potentially sensitive method to predict the risks for iron overload-related liver fibrosis in Chinese thalassemia patients.
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