Evidence map›Paper›PMID 28405317›Full record

ArticleUnited European gastroenterology journal2017

Changes in gene expression of neo-squamous mucosa after endoscopic treatment for dysplastic Barrett's esophagus and intramucosal adenocarcinoma.

Angelique Levert-Mignon, Michael J Bourke, Sarah J Lord, Andrew C Taylor, Antony R Wettstein, Melanie Edwards, Natalia K Botelho, Rebecca Sonson, Chatura Jayasekera, Oliver M Fisher and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Angelique Levert-MignonGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
Michael J BourkeDepartment of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia.
Sarah J LordGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia; School of Medicine, University of Notre Dame, Sydney, NSW, Australia.
Andrew C TaylorDepartment of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.
Antony R WettsteinDiagnostic Endoscopy Centre, St Vincent's Clinic, Sydney, NSW, Australia.
Melanie EdwardsSchool of Medicine, University of Notre Dame, Sydney, NSW, Australia; Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, NSW Australia.
Natalia K BotelhoGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
Rebecca SonsonDepartment of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia.
Chatura JayasekeraDepartment of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.
Oliver M FisherGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
Melissa L ThomasGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia; School of Medicine, University of Notre Dame, Sydney, NSW, Australia.
Finlay MacraeDepartment of Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Medicine, The University of Melbourne, Parkville, VIC, Australia.
Damian J HusseyDepartment of Surgery, Flinders University, Flinders Medical Centre Bedford Park, SA, Australia; Flinders Centre for Cancer Prevention and Control, Flinders University, Bedford Park, SA, Australia.
David I WatsonDepartment of Surgery, Flinders University, Flinders Medical Centre Bedford Park, SA, Australia; Flinders Centre for Cancer Prevention and Control, Flinders University, Bedford Park, SA, Australia.
Reginald V LordGastroesophageal Cancer Research Program, St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia; School of Medicine, University of Notre Dame, Sydney, NSW, Australia; Diagnostic Endoscopy Centre, St Vincent's Clinic, Sydney, NSW, Australia.
Flinders University · AUSt Vincent's Clinic · AUSt Vincent's Hospital Melbourne · AUThe University of Notre Dame Australia · AUWestmead Hospital · AUDouglass Hanly Moir Pathology · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic therapy, including by radiofrequency ablation (RFA) or endoscopic mucosal resection (EMR), is first line treatment for Barrett's esophagus (BE) with high-grade dysplasia (HGD) or intramucosal cancer (IMC) and may be appropriate for some patients with low-grade dysplasia (LGD).

objectiveThe purpose of this study was to investigate the molecular effects of endotherapy.

methodsmRNA expression of 16 genes significantly associated with different BE stages was measured in paired pre-treatment BE tissues and post-treatment neo-squamous biopsies from 36 patients treated by RFA (19 patients, 3 IMC, 4 HGD, 12 LGD) or EMR (17 patients, 4 IMC, 13 HGD). EMR was performed prior to RFA in eight patients. Normal squamous esophageal tissues were from 20 control individuals.

resultsEndoscopic therapy resulted in significant change towards the normal squamous expression profile for all genes. The neo-squamous expression profile was significantly different to the normal control profile for 11 of 16 genes.

conclusionEndotherapy results in marked changes in mRNA expression, with replacement of the disordered BE dysplasia or IMC profile with a more "normal" profile. The neo-squamous mucosa was significantly different to the normal control squamous mucosa for most genes. The significance of this finding is uncertain but it may support continued endoscopic surveillance after successful endotherapy.

Indexed as

Barrett’s esophagusendoscopic mucosal resectionesophageal adenocarcinomaesophageal neoplasmshigh-grade dysplasiaradiofrequency ablation

Identifiers

PMID28405317
PMCPMC5384557
OpenAlexW2395134620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.